Results 111 to 120 of about 1,299,385 (284)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
International Journal of Sports Physical Therapy, 2023 International Journal of Sports Physical Therapy
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
SportsBackground: Athletes with expertise in sports show extensive procedural and factual information, enhancing their ability to focus attention, use cues, and anticipate events.
Kuo-Cheng Wu +6 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
EludamosThis article analyses The Best Game, a fictional arcade game encountered in the YouTube animated series Bee and PuppyCat. Although arcade games in North America have long been conceptualised as sites of masculine skill-based competition and mastery ...
Jacqueline Moran
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
From Gaze to Game: A Systematic Review of Eye-Tracking Applications in Basketball
Brain SciencesBackground/Objectives: Eye-tracking technology has gained increasing attention in sports science, as it provides valuable insights into visual attention, decision-making, and motor planning. This systematic review examines the application of eye-tracking
Michela Alemanno +5 more
doaj +1 more source
Proposal to Sports Pharmacist as a Sports Doctor
YAKUGAKU ZASSHI, 2011 I am a team doctor of three competition groups including professional cycling team for ten years. The most troublesome issue as a sports doctor is the problem about doping. I cope thanks to a mobile telephone and an e-mail regardless of place and time, but introduce some examples because I still experience many doping "near miss" cases.
openaire +3 more sources