Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
The association between online learning and young people's participation in sports and its mediating mechanisms. [PDF]
Front Public HealthYang F.
europepmc +1 more source
'Exercise for the multitude, rather than competition for the specialist': British Sports Coaching Initiatives (1937-1947) [PDF]
, 2018 Dave Day
openalex
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Posterior Hamstring Harvest and Preparation for Quadruple Autograft All-Inside Anterior Cruciate Ligament Reconstruction. [PDF]
Video J Sports Medvan der List JP, Backs R, Kaeding CC.
europepmc +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The Competitiveness Evaluation and Empirical Research of Sports Tourism Industry for China's City
, 2013 Zhang Bing +4 more
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Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Clinical and Cosmetic Results After Double-Row Reconstruction of the Distal Triceps Tendon in an Athletic Population: A Retrospective Case Series of 70 Patients With a Mean Follow-up of 6 Years. [PDF]
Am J Sports MedFritsch L +6 more
europepmc +1 more source