Results 231 to 240 of about 672,672 (296)

Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3

open access: yesFEBS Open Bio, EarlyView.
PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno   +12 more
wiley   +1 more source

ENCOURAGEMENT OF SPORTS ACTIVITIES AMONG THE JAPANESE WORKERS

open access: bronze, 1963
Hiromasa Kita   +5 more
openalex   +2 more sources

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

open access: yesFEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li   +5 more
wiley   +1 more source

Studies of the “Sports-anemia”on the Athleters and Its Countermeasures (Report 1)

open access: bronze, 1961
Hisato Yoshimura   +11 more
openalex   +2 more sources

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

open access: yesFEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr   +5 more
wiley   +1 more source

EFFECTS OF DAILY SPORTS TRAINING ON THE PHYSICAL CONSTITUTION AND STRENGTH IN WORKING ADULTS

open access: bronze, 1963
Hiromasa KITA   +9 more
openalex   +2 more sources

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