Results 91 to 100 of about 1,173,222 (289)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Women?s Sports Club of Fargo, North Dakota Records, 1923-1925 [PDF]
, 2010 The Women?s Sports Club of Fargo Series consists of fifty-three unbound pages of handwritten text by Angela Boleyn including but not limited to the history, activities, including informal minutes, Constitution, songs, tournament results, newspaper ...
Boleyn, Angela +1 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Comparison case study on the "worker's participation in club management" for comprehensive community sports club [PDF]
, 2008 In the examination problem of the club management, What is particularly important is the realization of self-government process by club members in comprehensive community sports club.
村田, 真一 +4 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Club Objectives and Ticket Pricing in Professional Team Sports [PDF]
In this paper we analyze and compare the behavior of sports clubs in a profit and a win maximization league if the decisions on the optimal ticket price and the talent demand have to be made simultaneously.
Wilfried Pauwels, Stefan Kesenne
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Assessment of Kėdainiai sports club employees communication competence. [PDF]
, 2014 The object of: assessment of communication competence. The aim of: To rate communicative competence of sports club employees. Research problem: What communication competence reveal employees of sports club? Objectives of the: 1.
Mažeikienė, Gerda,
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source