Results 51 to 60 of about 607,713 (290)

Failure to meet aerobic fitness standards among urban elementary students [PDF]

open access: yes, 2018
The aim of this study was to explore the relationship of aerobic fitness with the elementary school environment and student characteristics among 4th and 5th grade children attending urban public schools in St. Louis, MO, USA.
Ackermann, Nicole   +7 more
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Research on the biomechanical laterality of athletes’ lower limbs during side kick in the competitive Taekwondo

open access: yesScientific Reports
Laterality between lower limbs can affects sports performance when Taekwondo athletes completing kicking movements, and Side Kick (SK) is the one of the most used kicking movements in Taekwondo competitions. Therefore, the aim of the present study was to
Ruifeng Huang   +5 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Extreme Sports: Are They Worth The Risk? [PDF]

open access: yes, 2012
Overview: Broken bones, head trauma, shark attacks, and casualties all while playing the sport you love. Is it worth it? With extreme sports come extreme risks.
Walin, Angela
core   +1 more source

Comparison of velocity-based and traditional 1RM-percent-based prescription on acute kinetic and kinematic variables [PDF]

open access: yes, 2018
Purpose: This study compared kinetic and kinematic data from three different velocity-based training (VBT) sessions and a 1-repetition maximum (1RM) percent-based training (PBT) session using full-depth, free-weight back squats with maximal concentric
Banyard, Harry G.   +4 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Challenges and recent progress in carbon-based nanocomposites for sportswear and sensing applications

open access: yesMaterials Research Express, 2023
Sportswear is an essential auxiliary wear for physical education activities in colleges and universities. Unfortunately, most sports equipment is made of heavyweight, expensive, and easily rusted metals.
Leiming Yang
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

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