Results 51 to 60 of about 280,456 (307)

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

open access: yesFEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig   +7 more
wiley   +1 more source

Leisure studies education: Historical trends and pedagogical futures in the United Kingdom and beyond [PDF]

open access: yes, 2014
This paper is an attempt to stimulate debate about the decline of leisure studies and the rise of courses and subject fields defined by sport, events, tourism management.
Aitchison   +10 more
core   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham   +7 more
wiley   +1 more source

Trans-urban Networks of Learning, Mega Events and Policy Tourism: The Case of Manchester's Commonwealth and Olympic Games Projects [PDF]

open access: yes, 2011
This paper argues for a rethinking of our understanding of what and where go into the ‘urban’ in the New Urban Politics (NUP). It contends that these issues have always been more complex, complicated and, most importantly, contested than has sometimes ...
Cook, Ian, Ward, Kevin
core   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin   +6 more
wiley   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein   +13 more
wiley   +1 more source

Neuropsychiatric Symptoms Mimicking Dementia in a Patient Treated With Imatinib

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Tyrosine kinase inhibitors are the cornerstone of chronic myeloid leukemia treatment. Newer agents have more potency and a broader spectrum of action, but also a higher potential for neuropsychiatric side effects. We present a case of a patient on imatinib who developed progressive cognitive, mood, and behavioral alterations.
Ashley Jones   +3 more
wiley   +1 more source

Women’s basketball at the Olympic Games [PDF]

open access: yesGeoSport for Society, 2015
The article refers to the evolution of Women Basketball Olympic Tournaments, trying to present and analyze these tournaments by associating the information related with the study of basketball to mapping representation.
Vasile GRAMA   +2 more
doaj  

Varadinum Summer School: Between perception and motivation [PDF]

open access: yesGeoSport for Society
The Romanian society is currently facing numerous challenges, among which the issue of school dropout is becoming increasingly prominent. The purpose of this study is to establish the relationship between the perception and motivation of the target group
Grigore Vasile HERMAN   +10 more
doaj   +1 more source

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