Results 101 to 110 of about 3,536,216 (337)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

肥満男性における心外膜脂肪組織の特徴 : 運動実践と食事制限による変化から [PDF]

open access: yes, 2009
Thesis (Ph. D. in Sports Medicine)--University of Tsukuba, (A), no.
金 孟奎
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Verification by experiment for upper-limb skeletal muscle activities during isokinetic muscle action of the shoulder joint [PDF]

open access: yes, 2009
Thesis (Ph. D. in Sports Medicine)--University of Tsukuba, (A), no.
朴 時英
core  

Revisiting the Sports Medicine as a specialty in professional training of sports doctors [PDF]

open access: yesСаратовский научно-медицинский журнал, 2017
 This article discusses expediency of deducing sports medicine in a separate educational specialty. Also, there is a new concept of sports medicine offered.
Razinkin S.M.   +2 more
doaj  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Measurement sites for predicting visceral adipose volume and cardiovascular risk factors in obese men [PDF]

open access: yes, 2013
Thesis (Ph. D. in Sports Medicine)--University of Tsukuba, (A), no.
蘇 リナ
core  

LncRNA NONHSAT248596.1 Promotes Osteoarthritis via miR-146a-5p/CXCR4 Axis by Inducing Chondrocyte Apoptosis and Extracellular Matrix Degradation

open access: yesJournal of Inflammation Research
Xianguang Yang,1 Guang Yang,2 Tengyun Yang,3 En Song,1 Yaoyu Xiang,1 Zhengliang Shi,1 Yue Yu,1 Guoliang Wang,1 Yanlin Li1 1Department of Sports Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People’s Republic of ...
Yang X   +8 more
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

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