Results 141 to 150 of about 3,152,440 (404)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

A MARKET OPPORTUNITY STUDY FOR THE DEVELOPMENT OF A NEW SPORT HORSE SERVICE AT THE MSU VETERINARY TEACHING HOSPITAL [PDF]

open access: yes
The potential need for several new services within the Veterinary Teaching Hospital (VTH) is unknown. However, based on focus groups and practitioner surveys conducted over the last several years, potential new services were identified: overnight ...
Larsen, Eric R., Lloyd, James W.
core   +1 more source

Clinical Guidelines in Sports Medicine: Am I Reading a Guideline or a Consensus Statement: What’s the Difference? Does it Matter? [PDF]

open access: yes, 2015
Introduction: The integration of research evidence into clinical practice is one of the most challenging aspects of sports medicine. The time required to search library databases and read multiple systematic reviews represents a significant barrier to ...
Grimmer, Karen   +2 more
core   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

open access: yesMolecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi   +5 more
wiley   +1 more source

PROJECT REPORT: A MARKET OPPORTUNITY STUDY FOR THE DEVELOPMENT OF A NEW ONCOLOGY SERVICE IN THE VETERINARY TEACHING HOSPITAL [PDF]

open access: yes
Current trends in veterinary medicine indicate the potential need for several new services within the VTH. Based on focus groups and practitioner surveys conducted in late 1998 and early 1999, potential new services could include oncology, overnight ...
Larsen, Eric R., Lloyd, James W.
core   +1 more source

American College of Sports Medicine Position Stand. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults.

open access: yesMedicine & Science in Sports & Exercise, 2009
Overweight and obesity affects more than 66% of the adult population and is associated with a variety of chronic diseases. Weight reduction reduces health risks associated with chronic diseases and is therefore encouraged by major health agencies ...
J. Donnelly   +5 more
semanticscholar   +1 more source

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

open access: yesMolecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen   +17 more
wiley   +1 more source

Competitive advantage of innovative technology in high performance sport training centres [PDF]

open access: yes, 2017
Sports technologies are part of the growing global sports and recreation industry. In the world of high performance sport, prominent sports stars and elite coaches are increasingly tapping into the world of technology and innovation to advance ...
Halenin, Roman Volodymyrovych   +3 more
core  

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