Results 221 to 230 of about 358,543 (289)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Risk Factors for Development of New-onset Anxiety and Depression After Sports Medicine Surgeries in Patients 25 Years of Age or Younger. [PDF]

J Am Acad Orthop Surg Glob Res Rev
Johnson AH, Brennan JC, York JJ, Redziniak DE, Petre BM, Turcotte JJ.   +5 more
europepmc   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Response to letter regarding: 'challenges confronted by paediatricians in evaluation of paediatric athletes: awareness on paediatric sports medicine'. [PDF]

Ann Med
Akkuş A, Aslan H, Ercan NB, Cığal B, Yücel M, Kılıç AO, Yazar A, Akın F.   +7 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Analysis of the Distribution of Private Research Funding to Sports Medicine Orthopaedic Surgeons. [PDF]

Orthop J Sports Med
Shah AK, Shah IK, Burkhart RJ, Gould HP, Calcei JG, Strickland SM, Voos JE.   +6 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Where will I end up? Relative location of sports medicine fellowship compared to residency among recent graduates. [PDF]

BMC Med Educ
Wen J, Park D, Razick D, Shehabat M, Syed B, Akhtar M, Maheta B, Goswami C, Pai N, Zhu A, Puglisi JL, Preiss-Farzanegan S.   +11 more
europepmc   +1 more source

The Sport Publication Observational Research Tool (SPORT): An Objective Tool to Score the Methodological Quality of Observational Clinical Sports Medicine Research. [PDF]

Orthop J Sports Med
Kuhn AW, Inclan PM, Haider AA, Christy MN, Dunn WR, Alberton L, Allen C, Anderson K, Andrews J, Azar F, Baer G, Banffy M, Bedi A, Brockmeier S, Brophy R, Bush-Joseph C, Carey J, Carter T, Cohen S, Farrow L, Flanigan D, Franklin C, Hame S, Ioannis T, Joseph S, Kenter K, Koh J, Krych A, LeClere L, Lee C, Levy B, McAllister D, Medvecky M, Morganti C, Musahl V, Nelson B, Noyes F, Owens B, Pace L, Paulos L, Redler L, Rodeo S, Safran M, Savoie F, Shelbourne D, Sherman S, Singer K, Smith M, Sonnery-Cottet B, Spiker A, Stuart M, Warren R, Wittstein J, Wolcott M, Wright R, Matava MJ.   +55 more
europepmc   +1 more source