Results 111 to 120 of about 22,002 (260)

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle

Advanced Science, EarlyView.
Repeated disuse imprints a molecular memory in skeletal muscle, conferring transcriptional resilience in young adults but exaggerated susceptibility in aged muscle, driven by epigenetic regulation of aerobic metabolism, mitochondrial and NAD+ pathways.
Daniel C. Turner, Truls Raastad, Max Ullrich, Stian F. Christiansen, Hazel Sutherland, James Boot, Eva Wozniak, Charles Mein, Emilie Dalbram, Jonas T. Treebak, Daniel J. Owens, David C. Hughes, Sue C. Bodine, Jonathan C. Jarvis, Adam P. Sharples   +14 more
wiley   +1 more source

Innovative Metasurface Colorimetric Cell‐on‐a‐Chip Sensor for Continuous, Label‐Free, Non‐Destructive Assessment of Intestinal Barrier Dynamics

Advanced Science, EarlyView.
We developed a real‐time, label‐free, high‐throughput cell‐on‐a‐chip system based on a metasurface plasmon resonance colorimetric sensor (MetaSPRCS) to evaluate intestinal barrier function. This platform enables continuous monitoring of cell adhesion, proliferation, and barrier layer formation, disruption, and repair.
Youqian Chen, Wen Li, Jiaying Feng, Yue Shu, Yihui Yang, Yuyan Wang, Rui Li, Hanlin Zhou, Xinfan Yang, Yuxue Guo, Mingqian Chen, Wenjun Hu, Gang Logan Liu, Liping Huang, Yanan Li   +14 more
wiley   +1 more source

Enhanced Photocatalytic Wastewater Purification and Bacterial Elimination via Copper Ion Irradiation‐Induced Modification of BiOCl

Advanced Science, EarlyView.
This study presents a copper ion irradiation method to achieve the modification function of BiOCl. By using high‐energy ion beams to introduce impurity ions inside the material, the intrinsic electric field of BiOCl is optimized, promoting the separation of photogenerated carriers and enhancing the photocatalytic activity.
Sihan Ma, Dewang Cui, Jianglong Kong, Wentao Li, Zheng Han, Yipeng Li, Shidong Zhang, Xinglin Yu, Deng Long, Xue Bai, Lin Wang, Guang Ran, Zhijun Zhao   +12 more
wiley   +1 more source

The use of nutritional supplements among male collegiate athletes

International Journal of Preventive Medicine, 2013
Background: The consumption of nutritional supplements is high in various sports, whereas, there are not enough documents supporting the beneficial effects of supplements in athletes.
Leila Darvishi, Gholamreza Askari, Mitra Hariri, Maryam Bahreynian, Reza Ghiasvand, Simin Ehsani, Nafiseh Shokri Mashhadi, Parva Rezai, Fariba Khorvash   +8 more
doaj  

Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy

Advanced Science, EarlyView.
This study constructed the W1/O/W2 emulsion–based targeted therapy delivery system for ulcerative colitis (UC) utilizing LCC as surfactant for the first time. This multifunctional emulsion offered certain therapeutic advantages for UC, including targeted colonic delivery of active compounds, synergistic modulation of gut microbiota through combined ...
Qian Wu, Xingyu Zhang, Jingjia Zhang, Gaohui Huang, Chen Zhou, Chunlin Li, Xiaojun Huang, Jianbo Xiao, Nianjie Feng, Yuanbin She   +9 more
wiley   +1 more source

Prevalence of Staphylococcus aureus carriage and pattern of antibiotic resistance, including methicillin resistance, among contact sport athletes in Italy

Infection and Drug Resistance, 2019
Valentina Mascaro,1 Maria Simona Capano,1 Teresa Iona,2 Carmelo Giuseppe Angelo Nobile,3 Antonio Ammendolia,2 Maria Pavia11Department of Health Sciences, University of Catanzaro “Magna Græcia”, Catanzaro, Italy; 2Department of Medical ...
Mascaro V, Capano MS, Iona T, Nobile CGA, Ammendolia A, Pavia M   +5 more
doaj  

Reply to “Comment on ‘De Novo Reconstruction of 3D Human Facial Images From DNA Sequence’”

Advanced Science, EarlyView.
ABSTRACT This manuscript is a formal response to the Comment by Wagner et al. regarding our publication “De Novo Reconstruction of 3D Human Facial Images from DNA Sequence.” We clarify the methodological rationale, analytical procedures, and scientific scope of our original study, and we address several misconceptions arising in the Comment. We further
Mingqi Jiao, Jiarui Li, Chunman Zuo, Sijia Wang, Luonan Chen   +4 more
wiley   +1 more source

Assessment of the relationship between frailty syndrome and the nutritional status of older patients

Clinical Interventions in Aging, 2019
Marta Muszalik,1 Mateusz Gurtowski,1 Halina Doroszkiewicz,2 Robbert JJ Gobbens,3–5 Kornelia Kędziora-Kornatowska11Department of Geriatrics, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Toruń, Poland; 2Department of ...
Muszalik M, Gurtowski M, Doroszkiewicz H, Gobbens RJJ, Kędziora-Kornatowska K   +4 more
doaj  

2023–2027 CAP First Pillar Reform and Livestock Sector: Production and Economic Impacts on Italian Specialized Dairy Cattle Farms

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT The present study uses an agroeconomic supply model to assess the impacts of 2023–2027 CAP on Italian specialized dairy cattle farms. The model considers the voluntary choice of Eco‐Scheme 1, specifically addressed to livestock farms, through the implementation of binary variables.
Davide Dell'Unto, Raffaele Cortignani
wiley   +1 more source