Results 91 to 100 of about 400,788 (314)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Doping in Sport: The Case of Fencing
Central European Journal of Sport Sciences and Medicine, 2016 Most athletes in order to achieve satisfactory results have to train long and hard. However, some of them, aiming at victory at all costs, resort to doping.
Maciej Łuczak
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The Challenge of Adapting the Rule of Law to Technological Developments
Jurnal Idea HukumThe problem in the digital era is that technology is developing rapidly without being accompanied by sufficient legal rules. Meanwhile, laws and regulations are always lagging and cannot achieve legal flexibility in society.
Emmilia Rusdiana
doaj +1 more source
Still on the Sidelines: Developing the Non-Discrimination Paradigm under Title IX [PDF]
, 1996 I. Introduction Despite the promises of equal opportunity for women signalled by the passage of Title IX of the Education Amendments of 1972 (Title IX), 1 little progress in the creditable realization of this goal occurred in intercollegiate or ...
Snow, Brian A., Thro, William E.
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Investigation of Ethical Dimensions in Sports Business Advertisement [PDF]
International Journal of Ethics and SocietyIntroduction: Adhering to advertising ethics can positively affect repeat purchases and customer loyalty. The purpose of this research was to investigate the ethical dimensions of sports business advertisements.
Ali Ghanbari +2 more
doaj
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
NANOTECHNOLOGY AND SPORT [PDF]
Sport Mont, 2010 We can say that sports are continuously evolving. To improve the quality of this work, changes are being made in all of these segments: development and selection of athletes, the improvement of technology for preparation and performance tactics, training
Zoran Mašić +2 more
doaj
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source