Results 101 to 110 of about 400,788 (314)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Sports regulation or the subject of sport law
NB: Административное право и практика администрированияThe article examines the phenomenon of "sport law", draws attention to the fact that this area of legal regulation is complex, due to the object of legal regulation - "sport". The author draws attention to various points of view regarding the subject of "sports law", and formulates the author's definition of this phenomenon.
openaire +1 more source
The Government’s Forward Regulatory Programme [PDF]
, 2010 Gives an overview of the Forward Programme, which identifies 308 regulatory changes that may be implemented between April 2010 up to and including April 2011 (comprising 265 new measures and 43 simplifications of existing measures).
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Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
SPORTS ORGANIZATIONS IN CIVIL LEGAL RELATIONS: PROBLEMS OF THEORY AND PRACTICE
Гуманитарные и юридические исследования, 2021 The article is based on relevant doctrinal sources. It deals with the peculiarities of Russian legislation on legal entities in the field of physical culture and sports.
Raisa Alekseevna Merzlikina +1 more
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Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Specificity of Employment Relations in Sports: Lessons from the National Context
Entertainment and Sports Law JournalEmployment relations in sports are shaped by the interplay of national legislation, international standards, and relations between the public sector and the sports movement.
Marko Begović
doaj +2 more sources
It’s time we made smoking history! Tobacco control in Malta : the present and the future [PDF]
, 1999 Tobacco products have no safe level of consumption. They are the only legal consumer products that cause ill health and premature death when used exactly as the manufacturer intends.
Sammut, Mario R.
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