Results 41 to 50 of about 243,546 (316)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Parents’ attitude to education of children in Children's and Youth Sports School

, 2014
Purpose: to determine the attitudes of parents of young athletes to the educational process in youth. Objectives: to identify the expectations of the respondents in relation to the objectives, factors, key actors of the educational process.
V.N. Mazin, Mazin V.N.
core   +1 more source

Relative age effects and implications for sport performance in elite Chinese junior male basketball players

BMC Pediatrics
Background The relative age effects (RAE) have been a hot topic in the field of sport research, and although the phenomenon has been found in most sports in China, there is currently no literature on the RAE phenomenon in Chinese basketball, which has ...
Jiaxin Deng, Yongfeng Liu, Tong Wang, Weicheng Li   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Influence of aerobic exercise on depression in young people: a meta-analysis

BMC Psychiatry
Objective To investigate the influence of aerobic exercise on depression among the young people. Data sources PubMed, Web of science, Embase, Cochrane, EBSCO were searched from inception to November 2023. Study selection RCT studies, assessing the use of
Weicheng Li, Yongfeng Liu, Jiaxin Deng, Tong Wang   +3 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The relationship between job crafting and professional identity among primary and secondary school physical education teachers: a chain mediation analysis

Frontiers in Psychology
BackgroundJob crafting is a proactive behavior through which teachers adjust their work tasks, relationships, and cognitions, and is positively associated with professional identity.
Yangyang Fu, Tong Liu, Zhonggen Yin, Zhonggen Yin, Qiang Guo, Duan Yu, Li Yang, Mingda Li   +7 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Empowering coaching in youth basketball: the balancing mechanism between coaching authority and athlete autonomy

Frontiers in Psychology
ObjectiveIn training practices, ingrained power dynamics between coaches and athletes often hinder the adoption of an “athlete-centered” approach, leading to diminished efficiency in sports training.
Junmin Zhang, Yongfeng Liu, Xiaogang Zhang, Ruobing Chen, Guang Feng, Shuiyou Hu   +5 more
doaj   +1 more source