Results 71 to 80 of about 243,546 (316)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Interpreting and Implementing the Long Term Athlete Development Model: English Swimming Coaches’ Views on the (Swimming) LTAD in Practice [PDF]

, 2010
The LTAD (Long Term Athlete Development) model has come to represent a sports-wide set of principles that significantly influences national sports policy in England.
Light, R, Melanie Lang, Lang, Melanie, Lang, M, Richard Light, Light, Richard   +5 more
core   +1 more source

Precision Exercise in Type 2 Diabetes Mellitus: Targeting Signaling Networks for Lipid Homeostasis

Metabolites
Type 2 diabetes mellitus (T2DM) is frequently complicated by dyslipidemia, which accelerates insulin resistance and the progression of cardiovascular and hepatic diseases.
Tan Tian, Feiyang Yu, Xingran Liu, Xuelin Zeng, Jianjun Yue, Shanjun Bao   +5 more
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

The feasibility of using circular training method for skiers-junior with regard typological properties nervous system

, 2014
Purpose: to determine the effect of a circular method of training on physical performance junior skiers depending on the strength of the nervous system. Material : the study involved 22 skiers (age 11 years).
Omelyanenko V. I., V. I. Omelyanenko
core   +1 more source

Comparison of post-activation performance enhancement in the lower limbs of short sprinters based on two velocity loss thresholds

Frontiers in Sports and Active Living
ObjectiveThe present study examined the effects of post-activation performance enhancement (PAPE) induced by different velocity loss (VL) thresholds on lower-limb explosive performance in sprinters under velocity-based resistance training (VBT).
Xiaohan Wang, Xiaohan Wang, Sidan Lu, Sidan Lu, Xinsong Cheng, Xinsong Cheng, Junjie He, Junjie He, Jianheng Wei, Jianheng Wei, Qihao Sun, Qihao Sun, Tian Zhou, Tian Zhou, Yin Yu, Yin Yu   +15 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Effect of variable resistance training on lower limb strength and power development: A training study [PDF]

, 2010
The ability to develop high levels of muscular strength and power is considered to be a critical component in many, if not most, sports. Because of this, new training methods are constantly being sought in an attempt to improve strength and power ...
Dobbs, Caleb W.
core  

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source