Results 131 to 140 of about 1,026,613 (311)

Unveiling key genetic loci and candidate genes for brown spot disease resistance in rice based on QTL analysis. [PDF]

Sci Rep
Zhao DD, Chung H, Farooq M, Kim NG, Choi SY, Kim S, Kim SM, Lee JH, Du XX, Kim KM.   +9 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Focal spot motion in digital breast tomosynthesis and its effect on spatial resolution. [PDF]

J Appl Clin Med Phys
Schaeffer CJ, Hulme KW, Rubinstein AE.
europepmc   +1 more source

There is a blind spot in AI research

Nature, 2016
Kate Crawford, Ryan Calo
semanticscholar   +1 more source

Spotted hyenas [PDF]

Current Biology, 2006
openaire   +2 more sources

Bier spots [PDF]

Canadian Medical Association Journal, 2012
Fang-Yih, Liaw, Chien-Ping, Chiang
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Sun-Spots [PDF]

Science, 1885
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

La «casta» y los «argentinos de bien»: narrativa electoral de Javier Milei

Más Poder Local
En el año 2023, frente a la mirada escéptica de una porción del arco político, Javier Milei se consagró presidente de Argentina. El flamante presidente inició su carrera mediática hacia el año 2016 con su participación en el programa Animales sueltos en
Andrea Ariza
doaj