Results 161 to 170 of about 723,629 (313)

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Do Individual Index Futures Investors Destabilize the Underlying Spot Market? [PDF]

open access: yes
This paper investigates the impact of introducing index futures trading on the volatility of the underlying stock market. We exploit a unique institutional setting in which presumably uninformed individuals are the dominant trader type in the futures ...
Christian A. Salm   +2 more
core  

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

Assessing the influence of spot price predictability on electricity futures hedging

open access: yes
A common feature of energy prices is that spot price changes are partially predictable due to weather and demand seasonalities. This paper follows the Ederington and Salas (2008) framework and considers the expected change in spot prices when minimum ...
Torro, Hipolit
core  

Color Balancing Mosaik Citra SPOT-6

open access: yes, 2015
Untuk keperluan mosaik citra satelit multitemporal, walaupun padasceneyangberbeda,namun untukobjek yang sama, seharusnya memiliki nilai derajat keabuannya sama.Mosaik citra yang seperti ini akan menghasilkan citra mosaik yang seamless.Citra SPOT-6yang ...
Liana Fibriawati, Haris Suka Dyatmika
core  

La «casta» y los «argentinos de bien»: narrativa electoral de Javier Milei

open access: yesMás Poder Local
En el año 2023, frente a la mirada escéptica de una porción del arco político, Javier Milei se consagró presidente de Argentina. El flamante presidente inició su carrera mediática hacia el año 2016 con su participación en el programa Animales sueltos en
Andrea Ariza
doaj  

Comparing 24 h Urine and Spot Urine Calcium Measurements in Clinical Routine: Accuracy and Limitations. [PDF]

open access: yesJ Clin Med
Mondorf A   +13 more
europepmc   +1 more source

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