Results 111 to 120 of about 1,970,120 (380)

Brucella NyxA and NyxB dimerization enhances effector function during infection

open access: yesFEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre   +4 more
wiley   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

open access: yesFEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt   +4 more
wiley   +1 more source

Las elecciones presidenciales del 2006 a través de los spots de campaña

open access: yesEspiral, 2007
Las campañas electorales por la presidencia de la República han propiciado un intenso debate en torno al sistema político mexicano. Uno de los temas que han adquirido mayor visibilidad es el de publicidad política en televisión. Ilustrado por los spots
Julio Juárez Gámiz
doaj  

Prevalence of Blue Spot among Mongolian Newborn Infants

open access: yesCentral Asian Journal of Medical Sciences, 2017
Objectives: The aim of this study was to determine the prevalence and characteristics of Mongolian spots in Mongolian infants. Methods: This hospital-based, descriptive cross-sectional study was conducted nationwide among 2641 newborn infants in ...
Suvd Batbaatar   +5 more
doaj   +1 more source

Reversed-polarity regions [PDF]

open access: yes
The 58 RPRS studied have a lifespan comparable to normal active regions and have no tendency to rotate toward a more normal alignment. They seem to have stable configurations with no apparent evidence suggesting stress due to their anomalous magnetic ...
Tang, F.
core   +1 more source

Large scale flow around turbulent spots

open access: yes, 2007
Numerical simulations of a model of plane Couette flow focusing on its in-plane spatio-temporal properties are used to study the dynamics of turbulent spots.Comment: 16 pages, 6 ...
Emmons H. W.   +5 more
core   +3 more sources

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

open access: yesFEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel   +2 more
wiley   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

open access: yesFEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche   +2 more
wiley   +1 more source

Rigorous assessment and integration of the sequence and structure based features to predict hot spots

open access: yesBMC Bioinformatics, 2011
Background Systematic mutagenesis studies have shown that only a few interface residues termed hot spots contribute significantly to the binding free energy of protein-protein interactions.
Wang Yong   +6 more
doaj   +1 more source

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