Results 221 to 230 of about 2,010,547 (381)

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Fuels Mediate the Influence of Climate Teleconnections on Wildfires in Dryland Ecosystems. [PDF]

Glob Chang Biol
Qu Y, Veraverbeke S, Miralles DG, Fan J, Vereecken H, Montzka C.   +5 more
europepmc   +1 more source

Bright spots of sustainable shark fishing

Current Biology, 2017
C. Simpfendorfer, N. Dulvy
semanticscholar   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

On the Great Sun-spot of June 1843* [PDF]

, 1871
Daniel Kirkwood
openalex   +1 more source

A New Tool to Decrease Interobserver Variability in Biomarker Annotation in Solid Tumor Tissue for Spatial Transcriptomic Analysis. [PDF]

Curr Issues Mol Biol
Palavalasa S, Baker E, Freeman J, Gokul A, Zhou W, Thomas D, Al-Holou WN, Morgan MA, Lawrence TS, Wahl DR.   +9 more
europepmc   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Exploring Blind Spots

Sociologisk Forskning, 2014
Johanna Esseveld
doaj   +1 more source

Sun-Spot Variation in Latitude 1861–1902 [PDF]

, 1904
WILLIAM J. S. LOCKYER
openalex   +1 more source

Artifacts in spatial transcriptomics data: their detection, importance, prevalence, and prevention. [PDF]

Brief Bioinform
Kummerfeld E, Williams L, Wang Y, Peters ST, Schmidt E, DuFresne-To M, Bernlohr D, Robbins P, Ikramuddin S, Adeyi O, Laux L, Barthel G, Johnson S, Wang J, Niedernhofer L, Nelson A, Aliferis C.   +16 more
europepmc   +1 more source