Results 101 to 110 of about 488,199 (315)

Mindfulness-Based Stress Reduction for Men on Active Surveillance for Prostate Cancer and Their Spouses: Design and Methodology of a Randomized Controlled Trial

open access: green, 2022
David Victorson   +10 more
openalex   +1 more source

Disease Burden and Coping Strategies of Spouses of Patients with Psoriasis: A Qualitative Study

open access: yesJournal of Multidisciplinary Healthcare
Min Wu,1,2,* Sining Zeng,3,* Yi Zhang,1,2,* Yanru Liu,1,2 Bingbing Li,1,2 Xuemei Yi,1,2 Yuling Shi,1,2 Xiaoping Zhu3 1Department of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, 200443, People’s ...
Wu M   +7 more
doaj  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Sickness Absence and the Effects of Having a Spouse - Can twins reveal the selection effect? [PDF]

open access: yes
Individuals that are married are often found to be healthier than singles. A crucial issue is to distinguish if this is due to a selection effect or due to a true protective effect of partnership. The purpose of this study is to distinguish these effects
Nilsson, william
core   +1 more source

A comparative analysis of burden of care and coping styles between wives of monosubstance- and polysubstance-dependent men

open access: yesIndustrial Psychiatry Journal
Background: Polysubstance dependence has emerged as a clinically distinct entity from monosubstance dependence, yet its impact on patients’ wives is understudied. Wives of substance-dependent men face a tremendous burden in their social lives, leading to
Poornima Khadanga   +2 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Household Decision Making in Rural China: Using Experiments to Estimate the Influences of Spouses [PDF]

open access: yes
Many economic decisions are made jointly within households. This raises the question about spouses' relative influence on joint decisions and the determinants of relative influence.
Carlsson, Fredrik   +4 more
core  

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