Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Predictive Factors of Sexual Compatibility in Married Women Referring to Selected Health Centers in Tehran, Iran [PDF]
نشریه پرستاری ایرانBackground & Aims Sexual compatibility is one of the important elements in sexual function, and is considered an important factor in the continuation of married life. Due to the multidimensional concept of sexual compatibility, it can be affected by many
Zahra Gorgi , Mansoureh Jamshidimanesh
doaj
How Could the Pension Funds Adjudicator Get it so Wrong? A Critique of Smith v Eskom Pension and Provident Fund [PDF]
Potchefstroom Electronic Law Journal, 2010 In this case note the judgment in the Smith case is criticized for being inconsistent with the landmark ruling in Volks. It is argued that the Adjudicator ought to have remanded the matter in Smith to the Board and ought to have ordered it to re-examine
N Dyani, M Mhango
doaj
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Testing for the Existence of Bargaining in Rural Households: a Study of Decisions on Labor Market Participation in the Cordillera Region of the Philippines [PDF]
In this paper we derive testable implications of a unitary farm household model and a non-unitary, i.e. bargaining, model. In the unitary household model the impact of spouse specific resources and non-labor income on household decisions should not be ...
Lodewijk Berlage +1 more
core
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Intra-Household Resource Management Structure and Income-Hiding under Incomplete Information [PDF]
There is evidence that some multi-person households may withhold income transfers, such as bonuses, gifts, and cash transfers, from other members of the household (Ashraf (2009); Vogler and Pahl, (1994)). In this paper, I show that the incentives to hide
Castilla, Carolina
core +1 more source
Getting Ready to Retire: Health Insurance Issues, August 2016 [PDF]
, 2016 Before making the decision to retire, understand the health insurance options available to you (and your spouse if you are married). Which questions you need to ask depends on: • how old you are. • how old your spouse is.
core
General Aspects on Matrimonial Regime of Legal Community. Common Assets in Condominium [PDF]
Journal of Humanistic and Social Studies, 2018 The current Romanian Civil legislation grants to the Matrimonial Regime of the Legal Community the prerogative of common law, applicable to patrimonial relations between spouses, when they do not derogate by concluding a matrimonial convention or opt ...
Miron Gavril Popescu
doaj
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source