Results 121 to 130 of about 467,030 (246)

Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial

British Journal of Clinical Pharmacology, EarlyView.
Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E64d in healthy volunteers.
Sebastian Fähndrich, Franziska Friedrich, Daniel Soriano, Jona Gjeloshi, Björn C. Frye, Xuan Phuoc Nguyen, Lydia Herbstritt, Caroline von Spee‐Mayer, Britta Lang, Fabrice Nollevaux, Andreas Hoheisel, Dorothee Winterberg, Armin Braun, Thomas Epting, Christine Contini, Karl Winkler, Thomas Reinheckel, Franziska C. Trudzinski, Gernot Rohde, Daiana Stolz, Robert Bals, Martin J. Hug, Sebastian Wirtz, Christoph Peters, Carolin Jenkner   +24 more
wiley   +1 more source

Domestic violence in Medellín and other municipalities of Aburrá Valley 2003-2004

Revista Facultad Nacional de Salud Pública, 2008
Objective: To estimate the magnitude and distribution by sex of domestic or family violence (between partners, siblings, and from parents to children) in Medellin, Colombia and nine surrounding municipalities (Medellin metropolitan area), 2003-2004 ...
Nilton E. Montoya, Luis F. Duque
doaj  

Breaking point: Identifying the factors that predict suspension from school

British Educational Research Journal, EarlyView.
Abstract School suspensions are associated with adverse educational and psychosocial outcomes, yet little is known about how structural disadvantage, relational factors, health behaviours, well‐being indicators and school‐level factors jointly predict suspension risk in England.
Stephanie Cahill, Roberto Vagnetti, Christopher Knowles, Emma Thornton, Qiqi Cheng, Neil Humphrey   +5 more
wiley   +1 more source

A beacon of inclusion for our whole community: Examining a civic university through the lens of LGBTQ+ inclusion

British Educational Research Journal, EarlyView.
Abstract This exploratory article explores how one UK university sought to understand and enhance its engagement with the local LGBTQ+ community. Drawing on poststructuralist queer and homonormative theories and civic university frameworks, the study analyses data from a community‐facing Pride survey completed by 53 LGBTQ+ individuals. Through emergent
Catherine Lee, Daniel Burman
wiley   +1 more source

Beyond the margins of silence: Pride Groups as opportunities for student voice

British Educational Research Journal, EarlyView.
Abstract Student voice and participation are widely promoted within educational research and policy; however, the voices of LGBT+ students, and the systems through which they might meaningfully participate, remain under‐theorised. Drawing on scholarship that conceptualises voice as multimodal and symbolic, and on literature that understands silence as ...
Adam Brett, Jo Brassington
wiley   +1 more source

A Prediction Model Based on Personality Traits and Domestic Violence Against Women and Child Abuse History Spouses in Isfahan

Salāmat-i ijtimā̒ī, 2017
Background and Objectives: In recent decades, violence against women, as the most serious social problem beyond cultural, social and regional remembered.
Soheila Shariat, Gholamreza Monshei
doaj  

Accelerating green heterocyclic synthesis: Convergence of AI, automation, and sustainable chemistry

Bulletin of the Korean Chemical Society, EarlyView.
Green heterocyclic synthesis and data‐driven tools such as AI, high‐throughput experimentation, continuous flow, and self‐driving laboratories have developed largely in parallel. This review connects them and asks how green metrics such as E‐factor and PMI might serve as explicit optimization targets rather than post‐hoc measures, toward sustainable ...
Noor Aisyah Ahmad Shah, Amirreza Mottafegh, Su‐Hyun Yoo, Jongwoon Kim, Minseon Byeon, Juhwan Noh, Yea‐Lee Lee, Jin Suk Myung, Gwang‐Noh Ahn   +8 more
wiley   +1 more source

Engineering programmable peptide hydrogels for chronic refractory wounds: A mechanism‐driven framework

BMEMat, EarlyView.
To break the self‐perpetuating pathology of chronic wounds, we propose a mechanism‐driven engineering framework for peptide‐based hydrogels. This review elucidates a hierarchical strategy—from molecular design to intelligent, multi‐functional systems—that enables these programmable biomaterials to dynamically intervene in key pathological loops and ...
Xiaoyu Lv, Xinyi Chao, Jiamin Zhang, Jianfeng Liu   +3 more
wiley   +1 more source

Cross-cultural measurement equivalence of the Revised Conflict Tactics Scales (CTS2) Portuguese version used to identify violence within couples

Cadernos de Saúde Pública
Following a previous evaluation of concept, item and semantic equivalences, this paper assesses the measurement equivalence between a Portuguese version of Revised Conflict Tactics Scales (CTS2) and the original instrument conceived in English.
Claudia Leite Moraes, Michael E. Reichenheim   +1 more
doaj  

A Business Framework for Product Take‐Back—A Structured Multiple‐Case Analysis

Business Strategy and the Environment, EarlyView.
ABSTRACT The potential of take‐back systems remains largely unrealized as initiatives have proven difficult to implement in practice. The question is why we do not see more take‐back systems given the substantial environmental benefits. We try to understand the challenges and stumbling blocks in setting up take‐back from a business perspective.
Rasmus Jørgensen, Torben Pedersen
wiley   +1 more source