Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Gestational diabetes and spousal health: the Finnish gestational diabetes study. [PDF]
Taskila T +7 more
europepmc +1 more source
Love and Money: A Theoretical and Empirical Analysis of Household Sorting and Inequality [PDF]
This paper examines the interactions between household matching, inequality, and per capita income. We develop a model in which agents decide whether to become skilled or unskilled, form households, consume and have children. We show that the equilibrium
John Knowles +2 more
core
Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham +7 more
wiley +1 more source
Psychological distress and its determinants among spouses of patients with familial clustering of hepatitis B virus-related hepatocellular carcinoma: A cross-sectional study. [PDF]
Wang Y +5 more
europepmc +1 more source
Couple's Relative Labor Supply in Intermarriage [PDF]
In this paper the hypothesis that partnerships between immigrants and natives are less specialized – in the sense that spouses provide similar working hours per weekday – than those between immigrants is tested.
Nottmeyer, Olga
core
Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein +13 more
wiley +1 more source
Dyadic coping, relationship quality, and psychosocial adaption between couples facing prostate cancer: A longitudinal cross-lagged study. [PDF]
Yuan X +6 more
europepmc +1 more source
Determinants of non-farm labour participation rates among farmers in Australia [PDF]
In recent decades, non‐farm employment has become prevalent and an important source of income for Australian farm families. However, models identifying the relative significance of the socioeconomic variables influencing non‐farm employment participation
Lim-Applegate, Hazel +2 more
core +1 more source
Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito +14 more
wiley +1 more source

