Results 31 to 40 of about 62,246 (245)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Networked Communication of the Iranian Family: Exploring How Spouses Redefine Privacy and Surveillance [PDF]
مطالعات رسانههای نوینThe impact of Information and Communication Technologies (ICTs), particularly the Internet, has led to the creation of two closely linked spheres of daily life, wherein daily life is formed in these two different yet interconnected spaces.
Saied Reza Ameli Renani +2 more
doaj +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
طب جانباز, 2018 Aims: War is a complex social event that affects institutions and social life. The purpose of this study was to compare the attachment styles, resilience and social capital in the spouses of witness, veterans and normal people.
M. Abbasi Abrazgah, SH. Khodaee
doaj
Formation of Marriage in the Slovak Law [PDF]
Societas et Iurisprudentia, 2018 The paper deals with the regulation of the formation of marriage in the Slovak family law. The author focuses on relationships between spouses which are created by a free decision of a man and a woman made in the form stipulated by the statute.
Róbert Dobrovodský
doaj
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Feasibility of Revocation in Spousal Donations Based on Jurisprudential Teachings (A Critique of Article 803 of the Civil Code with Proposed Amendments) [PDF]
آموزههای فقه مدنيThe Civil Code considers in Article 803, the presumption principle in the contract of gift (Arabic: اَلْهِبَة, Romanized: al-Hiba) to be permissible, and it states the exceptions where it becomes obligatory (presumed to be binding).
Amin Soleyman Kolvanaq
doaj +1 more source