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Postirradiation Sarcomas in Sprague-Dawley Rats
Radiation Research, 1998A series of radiation-induced neoplasms occurred in Sprague-Dawley rats 4-8 months after irradiation of a single hind leg with 60Co gamma rays. The rats were exposed to fractionated cumulative doses that ranged from 0 to 106 Gy. Osteosarcomas, malignant fibrous histiocytomas and fibrosarcomas developed in the radiation fields of a number of the rats in
Peggy T. Tinkey +5 more
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Intrauterine Expression of Prothrombin in the Sprague-Dawley Rat
Journal of the Society for Gynecologic Investigation, 2002Thrombin appears to underlie myometrial contractions in response to intrauterine bleeding. In a similar fashion, thrombin generated within the uterus in the absence of active bleeding could also produce contractions. These studies sought to determine whether functionally active prothrombin is expressed in the pregnant and nonpregnant rat uterus.
Mark Phillippe +4 more
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Olanzapine Induced Thrombocythemia in Sprague‐Dawley Rats
Drug and Chemical Toxicology, 2004Olanzapine was administered orally (20 mg/kg/day) in Sprague-Dawley rats. Forty-eight male Sprague-Dawley rats were divided into eight groups of six animals each. Four groups of animals received olanzapine for 7, 14, 21 and 48 days. There were no significant changes in hematological, clinical biochemistry parameters and superoxide dismutase activity in
Harish Padh +3 more
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Spontaneous leukaemia in a sprague-dawley rat
Experientia, 1962Description d'un cas de chloroleucemie myeloide chez un rat de souche Sprague-Dawley, presentant quelques modifications peu communes des tubes renaux.
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Carcinogenicity of 4-chloronitrosopiperidine in Sprague-Dawley rats
Zeitschrift f�r Krebsforschung und Klinische Onkologie, 19784-Chloronitrosopiperidine was administered to a group of 15 male Sprague-Dawley rats as a 0.005% solution in drinking water for 27 weeks. Of the 15 animals, 12 died with tumors induced by the treatment, half of them by the 41 st week; all 15 were dead at 58 weeks.
H. W. Taylor, W. Lijinsky
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The nephrotoxic potential of styrene in sprague-dawley rats
Toxicology Letters, 1983Pre-fasted (16 h) Sprague-Dawley male rats were treated i.p. with 0, 0.2, 0.4, 0.8 and 1.2 g/kg of styrene in corn oil. Renal functions were assessed at 0-24, 24-48 and 48-72 h after the exposure. Urinary creatinine was decreased at 0.8 g/kg of styrene during 0-24 h after the treatment compared to control, whereas such a decrease was noticed in 1.2 g ...
Jules Brodeur, Saroj K. Chakrabarti
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The Journal of Phytopharmacology, 2014
The present study was carried out to evaluate the hepatoprotective effects of aqueous extract of Xylopia aethiopica stem bark (XASB) on carbon tetrachloride (CCl4) induced liver damage in sprague dawley rats.
O. Adewale +4 more
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The present study was carried out to evaluate the hepatoprotective effects of aqueous extract of Xylopia aethiopica stem bark (XASB) on carbon tetrachloride (CCl4) induced liver damage in sprague dawley rats.
O. Adewale +4 more
semanticscholar +1 more source
Respiration in Sprague-Dawley Rats During Pregnancy
Inhalation Toxicology, 2006Minute ventilation and tidal volume increase in humans during pregnancy. Little data exists, however, on the respiration in pregnant rats, despite their widespread use as an animal model. Since respiration will affect the pharmacokinetics of volatile compounds and ultimately the dose to the fetus, we conducted a study to evaluate respiration in rats ...
David C. Dorman +5 more
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Lactational transfer of bisphenol A in Sprague–Dawley rats
Toxicology Letters, 2010Bisphenol A (BPA), an important industrial chemical to which humans are exposed on a daily basis, has long been associated with endocrine disruption in experimental animal models. Such exposures are of concern, particularly during fetal and early neonatal periods, because of greater vulnerability of developing organs to aberrant endocrine signaling ...
Michelle Vanlandingham +3 more
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Toxicity Studies of Epichlorohydrin in Sprague-Dawley Rats
Drug and Chemical Toxicology, 1996Adult male and female Sprague-Dawley rats received epichlorohydrin via gavage in distilled water for 10 consecutive days at dose levels of 3, 7, 19, and 46 mg/kg-day, and for 90 days at dose levels of 1, 5, and 25 mg/kg-day. Epichlorohydrin did not adversely effect mortality, but toxicity, at the higher doses, was evident by: 1) losses in body weight ...
Greg R. Olson +3 more
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