Results 191 to 200 of about 792,786 (268)

Methicillin-Resistant Staphylococcus Aureus Septic Internal Jugular Thrombophlebitis: A Case Report. [PDF]

Clin Pract Cases Emerg Med
Kowalczyk D, Ubiñas G.
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Effects of fasudil on disease spreading in ALS - A MUNIX-based post-hoc analysis of the ROCK-ALS trial. [PDF]

Neurotherapeutics
Wolff AW, Leha A, Koch JC, Demleitner AF, Neuwirth C, Friede T, Weber M, Lingor P.   +7 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Intracranial Retrograde Cerebrospinal Fluid Dissemination of H3 K27-altered Glioma. [PDF]

J Neurol Surg Rep
Patel P, Battiste J, Fung KM, Dunn IF, Graffeo CS.   +4 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Tau positron emission tomography analysis methods for the quantification of tau spread in preclinical and early Alzheimer's disease. [PDF]

Alzheimers Dement
Wong J, Wang T, Datta R, Abdollahi RO, Li J, Rowe CC, Henley D, Kolb HC, Saad ZS, Alzheimer's Disease Neuroimaging Initiative.   +9 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Single Epididymis Metastasis 12 Years After Radical Prostatectomy: A Case Report and Literature Review. [PDF]

Case Rep Urol
Fanelli A, Troiano F, Guzzi F, Finati M, Ricapito A, Selvaggio O, Falagario U, Busetto GM, Cormio L, Bettocchi C, Carrieri G.   +10 more
europepmc   +1 more source

Kumskova M, Flora GD, Nayak MK, et al. Platelet defects in patients and mice with Ehlers-Danlos syndrome. Blood. 2026;147(9):987-997.

Blood
europepmc   +1 more source