Results 141 to 150 of about 1,531,741 (269)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Tau positron emission tomography analysis methods for the quantification of tau spread in preclinical and early Alzheimer's disease. [PDF]

Alzheimers Dement
Wong J, Wang T, Datta R, Abdollahi RO, Li J, Rowe CC, Henley D, Kolb HC, Saad ZS, Alzheimer's Disease Neuroimaging Initiative.   +9 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Networks of Indirect Contact Promote Spread of an Environmentally Transmitted Pathogen in a Highly Social Species. [PDF]

Ecol Evol
Leitch JR, Jordan NR, Drake JM, Cant MA, Alexander KA.   +4 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Assessment of Risk to the U.S. Population from the Ebola Disease Outbreak Caused by Bundibugyo Virus, 2026. [PDF]

MMWR Morb Mortal Wkly Rep
Richard DM, Routledge I, Koeller S, Ghinai I, Hsu CH, Chatham-Stephens K, Bruce BB, Kahn R, Holmdahl I.   +8 more
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Corrigendum to "RESEARCH NOTE: First Report of Very Virulent Infectious Bursal Disease Virus in Benin: Molecular Characterization and Implications for Transboundary Spread" [Poultry Science, Volume 104, 2025, 105966]. [PDF]

Poult Sci
Wang H, Codjia RC, Xiao H, Wang C, Yang X, Wang X.   +5 more
europepmc   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Integration of Developed Mathematical Model for Predicting and Monitoring the Spread of Epidemics and Pandemics: The Case of COVID-19 in Rwanda. [PDF]

Public Health Chall
Ntaganda JM, Ngaruye I, Ndanguza D.
europepmc   +1 more source