Results 121 to 130 of about 3,568,047 (295)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
HF radar observations of equatorial spread-F over West Africa
Annales GeophysicaeNew experimental data depicting equatorial spread-F were taken during an HF radar sounding campaign in Korhogo (Ivory Coast, 9°24N, 5°37W, dip 4°S). Range-time-intensity maps of the radar echoes have been analyzed to identify the signatures of density ...
J.-F. Cécile, P. Vila, E. Blanc
doaj
Evaluation of Automated Spread–F (SF) Detection over the Midlatitude Ionosphere
AtmosphereThe present study evaluates an automated Spread–F (SFP) detection algorithm by integrating SF-related (QF, FF) and ionospheric parameters (hmF2, h’F), acting as an indicator for SF events, from SAO Explorer auto-scaled (ARTIST) data, compared to manually
Krishnendu Sekhar Paul +2 more
doaj +1 more source
Precise time and time interval (PTTI), an overview [PDF]
Present applications of precise time and frequency (T/F) technology can be grouped as follows: (1) Communications systems which require T/F for time division multiplexing and for using spread spectrum techniques. (2) Navigation systems which need T/F for
Winkler, G. M. R.
core +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source