Results 151 to 160 of about 745,809 (314)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Predicting Agency Rating Migrations with Spread Implied Ratings [PDF]
Investors traditionally rely on credit ratings to price debt instruments. However, rating agencies are known to be prudent in their approach to rating revisions, which results in delayed ratings adjustments to mutating credit conditions.
Jianming Kou, Dr Simone Varotto
core
Spread Construction for (36,15,6) Hadamard Difference Sets
There are exactly 35 inequivalent (36, 15, 6) difference sets in nine groups. Eight of the nine groups have a normal Sylow 3-subgroup. We give a straightforward spread construction which explains the 32 inequivalent difference sets in these eight groups. An interesting variation on this construction provides the three difference sets in the ninth group.
Smith, Ken, Webster, Jordan
openaire +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
A new description of uniformly spread discrete sets
We prove that each discrete set in the Euclidean space that has bounded changes under every translation is a bounded perturbation of a square lattice, i.e., a uniformly spread set in the sense of Laszkovich. In particular, the support of every Fourier quasicrystal with unit masses is uniformly spread.
Dudko, A., Favorov, S.
openaire +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Formalism or Substantialism: ESG and Stock Crash Risk
We use a specifically chosen data set of Chinese A-share listed businesses from 2009 to 2022 to investigate the complex relationship between stock crash risk and company Environmental, Social, and Governance (ESG) performance.
Jin, Ziping
core +1 more source