Results 201 to 210 of about 6,473,918 (315)

Modelling the impact of awareness campaigns on HPV transmission dynamics: a neural network-enhanced mathematical model. [PDF]

Sci Rep
Shah K, Du C, Akgül A, Alshammari FS, Bajri SA, El-Wahed Khalifa HA.   +5 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Rationale and design of the SPREAD study : Sport Practice and its Effects on Aortic Size and Valve Function in Bicuspid Aortic Valve Disease

: The bicuspid aortic valve (BAV) is the most common congenital heart defect among adults, often leading to severe valve dysfunction and aortic complications.
Eijsvogels, Thijs M., Moreo, Antonella, Cavarretta, Elena, Zamorano, Jose L., Ragazzoni, Gian Luca, van Craenenbroeck, Emeline, D'Ascenzi, Flavio, De La Garza, Maria Sanz, Cavigli, Luna, Halle, Martin, Boncompagni, Alex, Mantegazza, Valentina, Galian-Gay, Laura, Pelliccia, Antonio, Stefani, Laura, Claessen, Guido, D'Andrea, Antonello   +16 more
core  

Novel Detection Marker of Xanthomonas fragariae from Strawberry Plants Using SYBR Green Real-Time PCR. [PDF]

Plant Pathol J
Choi HS, Ki S, Lee YH, Ham H.
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Systematic review of modelling approaches assessing eradication and containment measures for the pinewood nematode (PWN) <i>Bursaphelenchus xylophilus</i>. [PDF]

EFSA J
EFSA Panel on Plant Health (PLH), Civera AV, Baptista P, Berlin A, Chatzivassiliou E, Cubero J, Cunniffe N, de la Peña E, Desneux N, Di Serio F, Filipiak A, Gonthier P, Hasiów-Jaroszewska B, Jactel H, Landa BB, Maistrello L, Makowski D, Milonas P, Papadopoulos NT, Potting R, Susi H, van der Gaag DJ, Bonifacio L, Urek G, Crotta M, Gobbi A, Kaczmarek A, Mijic D, Pautasso M, Thulke HH.   +29 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

System-Level Hardware-Waveform Co-Design for Micro-UAV Radar Sensors: Suppressing Noise Folding in Extreme SWaP-C SSDBF Arrays. [PDF]

Sensors (Basel)
Dai X, Xie K, Wang Y.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Exonuclease Ribozyme Encoded in a Circular Genome: On the Initiation of the RNA World. [PDF]

Life (Basel)
Liang M, Yu C, Jiang H, Ma W.
europepmc   +1 more source