FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
The Impact of Northern Territory Alcohol Policy Changes on Adult Domestic and Family Violence Hospital Admissions. [PDF]
Drug Alcohol RevClifford S +5 more
europepmc +1 more source
Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora
FEBS Open Bio, EarlyView.This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi +6 more
wiley +1 more source
Genome-resolved metagenomic survey of 500 samples from 56 hot springs across the Western US. [PDF]
Sci DataKorchagina MV +12 more
europepmc +1 more source
Ionic Wind Cooling Enables High-Frequency Shape Memory Alloy Actuators for Origami-Inspired Soft Robotics. [PDF]
SmallZhang F +6 more
europepmc +1 more source
Radioactive Springs and Archaeal Life in Deep Groundwater Systems. [PDF]
Microb EcolEckertová T +3 more
europepmc +1 more source
Kissing Rectal Ulcers With Associated Occult Rectal Mucosal Prolapse: A Distinct Endoscopic Presentation of Solitary Rectal Ulcer Syndrome in an HIV Positive Patient With Comprehensive Infectious Exclusion. [PDF]
Case Rep Gastrointest MedGanju N +6 more
europepmc +1 more source
Simulating the Impacts of Deep Geothermal Development on Shallow Hydrothermal Resources in a Rocky Mountain Rift Valley. [PDF]
Ground WaterRush MJ +5 more
europepmc +1 more source