Results 31 to 40 of about 185,380 (253)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Annals of Human BiologyBackground The Old Friends Hypothesis suggests limited exposure to symbionts during development leads to immune system dysregulation (e.g. allergies, autoimmunity) and inflammatory conditions (e.g.
Courtney Manthey +2 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Geosciences, 2017 Water in arid and semi-arid environments is characterized by the presentation of complex interactions, where dissolved chemical species in high concentrations have negative effects on the water quality.
Marusia Rentería-Villalobos +3 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Revista Ambiente & Água, 2009 The objective of this work was to evaluate hydrological and environmental issues of Cachoeira das Pombas watershed, in Guanhães, eastern Minas Gerais State, Brazil, to support its management plan.
Deuseles João Firme +5 more
doaj +1 more source
Approaches to Advising Incoming College Students with Dual Enrollment Credit
Journal of College Orientation, Transition, and Retention, 2020 Academic advisors in higher education are often incoming students’ first exposure to college curriculum and academic expectations. Additionally, academic advisors serve as an on-going support to students throughout their college careers. As the number of
Patricia Witkowsky +4 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Forest Science and Technology, 2019 The research aimed to analyze the distribution of trees species around springs in various environmental factors and the trees-springs interplay possibility in Soloraya region, Indonesia. Investigation was conducted by survey using census method within 10
Siswo, Chung Weon Yun, Susi Abdiyani
doaj +1 more source