Results 31 to 40 of about 93,765 (263)

Regioselective Reduction of 1H-1,2,3-Triazole Diesters

open access: yesMolecules, 2021
Regioselective reactions can play pivotal roles in synthetic organic chemistry. The reduction of several 1-substituted 1,2,3-triazole 4,5-diesters by sodium borohydride has been found to be regioselective, with the C(5) ester groups being more reactive ...
Christopher R. Butler   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Hydrochemistry and 222Rn Concentrations in Spring Waters in the Arid Zone El Granero, Chihuahua, Mexico

open access: yesGeosciences, 2017
Water in arid and semi-arid environments is characterized by the presentation of complex interactions, where dissolved chemical species in high concentrations have negative effects on the water quality.
Marusia Rentería-Villalobos   +3 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Childhood developmental environment affects adult intestinal inflammation levels: preliminary evidence from older adults in the United States

open access: yesAnnals of Human Biology
Background The Old Friends Hypothesis suggests limited exposure to symbionts during development leads to immune system dysregulation (e.g. allergies, autoimmunity) and inflammatory conditions (e.g.
Courtney Manthey   +2 more
doaj   +1 more source

Hydrological and environmental diagnostic of the Cachoeira das Pombas’s watershed, Guanhães, MG, Brazil

open access: yesRevista Ambiente & Água, 2009
The objective of this work was to evaluate hydrological and environmental issues of Cachoeira das Pombas watershed, in Guanhães, eastern Minas Gerais State, Brazil, to support its management plan.
Deuseles João Firme   +5 more
doaj   +1 more source

Biophysical approaches for studying viral entry

open access: yesFEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Distribution of tree species around springs and trees-springs interplay possibility in the springs area of Soloraya, Central Java, Indonesia

open access: yesForest Science and Technology, 2019
The research aimed to analyze the distribution of trees species around springs in various environmental factors and the trees-springs interplay possibility in Soloraya region, Indonesia. Investigation was conducted by survey using census method within 10 
Siswo, Chung Weon Yun, Susi Abdiyani
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

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