Results 131 to 140 of about 13,339 (340)
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Photograph of farmers and workers with horses and donkeys on a road in Sprinkle, TX. Barr is the gentleman seated in one of the horse and buggies.
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Mary Elizabeth Sprinkle Vaughn with grandsons
, 1910 Photograph shows (left to right) Bill Vaughn, Mary Elizabeth Sprinkle Vaughn, and Marion Vaughn standing in front of backdrop outside residence.Inscription on back:""Grandma Vaughn / Bill and Marion.
Lacey, David Clayton.
core
Planetary Lovers: On Annie Sprinkle and Beth Stephens’s Water Makes Us Wet
, 2019 This chapter examines Annie Sprinkle and Beth Stephens’s “sexecology,” a multi-year art and activist project that presents the earth as lover, source, and receiver of polymorphous pleasures.
Miriam Tola, Tola, Miriam
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Beyond Queer Fear? Turbulent Times for Supervision in Ministry
, 2019 Sprinkle revisits his 2008 essay, “Queer Fear” and updates readers on what is the same, what is different, summarizing the social, cultural and political dynamics that create a climate of fear for LGBTQIA ...
Sprinkle, Stephen V.
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Evaluation of 1977 Asphalt Concrete Sprinkle Treatments; HR-1012, December 1980 [PDF]
, 1980 Iowa's first sprinkle treatment in 1974 was applied to a short section of old US 30 west of Ames. A roll type seal coat spreader was used to apply several types of sprinkle aggregates.
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source