Results 111 to 120 of about 58,392 (310)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Sprint Training Versus Hollow Sprint : Which Method is Better on Base Running Speed

Active: journal of physical education, sport, health and recreation, 2019
This study aims at knowing the effect of sprint training and hollow sprint exercises on running speed of base running and knowing which method is better between sprint training and hollow sprint on base running speed for male students of softball ...
Amirudin Fathoni , Hari Amirullah Rachman   +1 more
doaj  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Effect of expertise on pacing strategies and sprint performance in batsmen

, 2018
Objectives To assess whether the absence of a known endpoint, at the beginning of repeated-sprint bouts between the wickets, affects how skilled compared to less skilled batsmen pace themselves. Design Repeated measures.
Steenekamp, T., Travis Steenekamp, Pote, L., Andrea Elliot, Francois Billaut, Elliot, A., Candice J. Christie, Lee Pote, Billaut, F., Timothy D. Noakes, Christie, C.J., Noakes, T.D.   +11 more
core   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Effects of Sand Surface Plyometric and Sprint Training on Physical and Technical Skill Performance in Beach Handball Players [PDF]

This study compared the effects of a 6-week combined plyometric and sprint-training program on the sand to regular preseason training, on the athletic performance and technical actions of beach handball (BH) players.
Ramirez-Campillo, Rodrigo e, Alcaraz, Pedro E., Feito-Blanco, Javier, Ortega Becerra, Manuel, Calleja-González, Julio, Calleja González, Julio María, Feito Blanco, Javier, Ramírez Campillo, Rodrigo, Sáez de Villarreal, Eduardo, Rascón, Pedro Bago, Bago Rascón, Pedro   +10 more
core   +1 more source

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Recovery and adaptation from repeated intermittent sprint exercise

, 2014
PURPOSE: This investigation aimed to 1) ascertain a detailed physiological profile of recovery from intermittent sprint exercise on athletes familiar with the exercise, and 2) investigate if athletes receive a protective effect on markers of exercise ...
Howatson, Glyn, Gaze, D.C., Leeder, Jonathan, Jewell, A., Shah, I., van Someren, K., Gaze, Dave, Deshmukh, Nawed, Shah, Iltaf, Barker, J., Jewell, Andrew, Leeder, Jonathan D.C., Gaze, David, van Someren, Ken, van Someran, Ken A., Howatson, G., Leeder, J., Deshmukh, N., Barker, James   +18 more
core   +1 more source