Results 1 to 10 of about 113,106 (354)
POT1-TPP1 binding stabilizes POT1, promoting efficient telomere maintenance
Computational and Structural Biotechnology Journal, 2022 Telomeric POT1-TPP1 binding is critical to telomere maintenance and disruption of this complex may lead to cancer. Current data suggests a reduction of intracellular POT1 levels in the absence of TPP1.
Tomas Aramburu +3 more
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The Cosmopolitanization of the EU’s Borders?
PORTAL: Journal of Multidisciplinary International Studies, 2007 For centuries the political geography of Europe has been based around borders of its nation states. The ability of the nation state to control its territory has been essential to the practices of war and diplomacy, the legitimacy of governments ...
Damian Spruce
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Molecular Therapy: Oncolytics, 2022 Glioblastoma is an aggressive tumor with poor survival rates. Bispecific T cell engagers (BTEs) against different cancers are in various stages of clinical development.
Pratik S. Bhojnagarwala +9 more
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Molecular Therapy: Oncolytics, 2022 Latent Epstein-Barr virus (EBV) infection is associated with several types of cancer. Several clinical studies have targeted EBV antigens as immune therapeutic targets with limited efficacy of EBV malignancies, suggesting that additional targets might be
Xizhou Zhu +13 more
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Hydroxyacetophenone defenses in white spruce against spruce budworm [PDF]
Evolutionary Applications, 2019 AbstractWe review a recently discovered white spruce (Picea glauca) chemical defense against spruce budworm (Choristoneura fumiferana) involving hydroxyacetophenones. These defense metabolites detected in the foliage accumulate variably as the aglycons, piceol and pungenol, or the corresponding glucosides, picein and pungenin.
Parent, GJ +7 more
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Widespread micronodular hepatic metastases of neuroendocrine tumor detected by [68Ga]DOTATATE PET/CT
Radiology Case Reports, 2023 Neuroendocrine tumors (NET) encompass a diverse, heterogeneous group of neoplasms that originate from the secretory cells of the neuroendocrine system. These neoplasms typically express the somatostatin receptor (SSTR), which can be targeted by molecular
Julia C. D'Souza, MD, MS +4 more
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Synthetic DNA Delivery of an Engineered Arginase Enzyme Can Modulate Specific Immunity In Vivo
Molecular Therapy: Methods & Clinical Development, 2020 Arginase is a complex and unique enzyme that plays diverse roles in health and disease. By metabolizing arginine, it can shape the outcome of innate and adaptive immune responses. The immunomodulatory capabilities of arginase could potentially be applied
Makan Khoshnejad +12 more
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POT1-TPP1 telomere length regulation and disease
Computational and Structural Biotechnology Journal, 2020 Telomeres are DNA repeats at the ends of linear chromosomes and are replicated by telomerase, a ribonucleoprotein reverse transcriptase. Telomere length regulation and chromosome end capping are essential for genome stability and are mediated primarily ...
Tomas Aramburu +2 more
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NeuroImage: Clinical, 2022 Background and Purpose: Dysfunction of the blood–brain-barrier (BBB) is a recognized pathological consequence of traumatic brain injury (TBI) which may play an important role in chronic TBI pathophysiology.
Jeffrey B. Ware +13 more
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