Results 141 to 150 of about 3,761,140 (303)

Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia

Advanced Science, EarlyView.
This study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA) on lung development and autophagic flux. IPA alleviates hyperoxia‐induced alveolar arrest by promoting autophagosome‐lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.
Beibei Wang, Xu Chen, Haowei Xu, Zhiqi Zeng, Keyu Lu, Yu Mao, Qianru Lv, Hui Shi, Song Liu, Xian Shen, Chunyu Yin, Yang Yang, Yan Guo, Xingyun Wang, Rui Cheng   +14 more
wiley   +1 more source

Long‐Term Elevated CO2 Improves Soil Health and Rice Yields in Paddy Fields

Advanced Science, EarlyView.
Combining the two longest‐running rice free‐air CO2 enrichment experiments with a global data synthesis, this study demonstrates that long‐term elevated CO2 consistently enhances soil health. In rice paddies, this improvement sustains the CO2 fertilization effect over decades.
Fan Jiang, Wenchao Du, Kees Jan van Groenigen, Josep Peñuelas, Scott X. Chang, Lian Song, Chuang Cai, Yu Wang, Lin Deng, Zhengkun Hu, Weishou Shen, Qicong Wu, Haiyang Yu, Ying Yin, Fuxun Ai, Wei Zhou, Dongming Wang, Jianqiang Sun, Xiaoyuan Yan, Renfang Shen, Jiabao Zhang, Hongyan Guo, Chunwu Zhu   +22 more
wiley   +1 more source

Multi-omics analysis reveals the mechanism of <i>Lactobacillus plantarum</i> in alleviating metabolic disorders in type 2 diabetic mice through the gut-liver axis. [PDF]

mSystems
Zhang C, Gao Y, Huang Y, Qin Y, Li Y, Chen Q, Wu T, Zhang Y, Zhang Y, Deng D, Huang B, Chen M, Han M.   +12 more
europepmc   +1 more source

SPSS

, 2021
openaire   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Herbal Neuroprotection Meets Stress-Induced Neuropathology: Bojungikgi-Tang Modulates the Hypothalamic-Pituitary-Adrenal Axis and GABAergic Pathways in Post-Traumatic Stress Disorder. [PDF]

Biomedicines
Cai M, Park HR, Yang EJ.
europepmc   +1 more source

Cahiers de l'IMA : Fascicule SPSS [PDF]

, 2008
Gilles, I., Green, E. G. T., Ricciardi-Joos, P., Scheidegger, R., Storari, C., Tuescher, T., Wagner, P.   +6 more
core  

DRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut

Advanced Science, EarlyView.
Dopamine receptor D2 (DRD2) deficiency disrupts epithelial barrier integrity in both the gut and pituitary gland, facilitating translocation of gut‐derived Escherichia coli into pituitary tissue. Intratumoral E. coli are phagocytosed by microglia, triggering GSDMD‐dependent pyroptosis and HMGB1 release, which subsequently activates MAPK signaling to ...
Xian‐jun Su, Li Ma, Xi Xiong, Jun‐hua Meng, Qi Wu, Yu Zhang, Shu‐guang Dong, Yue‐fei Wang, Jin‐hu Wu, Qing‐yuan Zeng, Hong‐feng Zhang, Li‐li Li, Liang Meng, Min Peng, Xiao‐dong Huang, Li‐quan Wu, Xiong Wang   +16 more
wiley   +1 more source

Research Communication: The Cumulated Spontaneous Portosystemic Shunts (SPSS) Area Decreases After TIPS and Impacts on Prognosis. [PDF]

Aliment Pharmacol Ther
Hintersteininger M, Müllner-Bucsics T, Riegler S, Dominik N, Kramer G, Sebesta C, Thöne P, Asenbaum U, Reider L, Schoder M, Trauner M, Mandorfer M, Reiberger T, Hartl L, Lampichler K.   +14 more
europepmc   +1 more source

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

Advanced Science, EarlyView.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon, Kyungchul Noh, Minkyu Hwang, Yoon‐Jung Kim, Unjin Lee, Yeon Joo Ryu, Je‐Kyung Ryu, Sang Beom Jun, Se‐Young Choi, Woo‐Hyun Cho, Sung Joong Lee   +10 more
wiley   +1 more source