This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei +10 more
wiley +1 more source
Response to the letter to the editor: Immediate effects of posture correction taping on pain, cervical range of motion, and scapulothoracic muscle activity in individuals with forward head posture and mechanical neck pain: a randomized controlled trial in India. [PDF]
M GB, Bhat SN, H S, Rao BK.
europepmc +1 more source
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang +18 more
wiley +1 more source
Associations between cyberbullying victimization and cyberbullying: a three-wave longitudinal moderated mediation model. [PDF]
Wu J, Gao Y, Xiao Q, Hao Q, Liu Z.
europepmc +1 more source
Millennium Cohort Study First Survey: A Guide to the SPSS Dataset (3rd Edition) [PDF]
Dex, Shirley +3 more
core +1 more source
FLARE, a multimodal AI framework, combines pathology slides, radiology scans, and clinical reports to predict colorectal cancer outcomes, even when some tests are missing. Evaluated retrospectively in 1679 patients from four medical centers, it consistently achieved the best prognostic accuracy and clearly separated high‐ and low‐risk groups.
Linhao Qu +6 more
wiley +1 more source
Keratoconus: A Probe Into the Refractive Symmetry. [PDF]
Saha S +4 more
europepmc +1 more source
The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley +1 more source
Effect of postoperative analgesia with the combination of dexmedetomidine and butorphanol after spinal posterior surgery: a randomized controlled trial. [PDF]
Xie ZF +6 more
europepmc +1 more source

