Results 41 to 50 of about 2,178,365 (291)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Statistical analysis of the relation between human age and gender on the risk of death from cancer in head and neck CT-Scan [PDF]
مجله علوم و فنون هستهایThe purpose of this study was to investigate the effects of human age and gender on the estimation of the death risk due to cancer in head and neck CT scans.
R. Ahangari, M. Abdolalizadeh
doaj +1 more source
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Journal of Architectural Sciences and ApplicationsThis study aims to assess the professional awareness and career planning of undergraduate and associate degree students in two cities with landscape education infrastructure.
Ahmet Koç, Esra Özhancı
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Aksioma: Jurnal Program Studi Pendidikan Matematika, 2021 One of the factors causing the low score of student learning outcomes Statistics and Probability on midterm exams is that during practice or studying on their own, students feel the complexity of solving questions about data analysis in Statistics and ...
Herlina Herlina
doaj +1 more source
, 2017 This paper aims to introduce multilevel logistic regression analysis in a simple and practical way. First, we introduce the basic principles of logistic regression analysis (conditional probability, logit transformation, odds ratio).
N. Sommet, D. Morselli
semanticscholar +1 more source
Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham +7 more
wiley +1 more source
Gouvernance des Petites et Moyennes Entreprises dans la commune de Kinshasa [PDF]
Mouvements et Enjeux SociauxLes résultats de cette étude attestent de l’existence d’une forte corrélation entre la gouvernance et les performances dans les petites et moyennes entreprises familiales. Les performances des dirigeants des PME dans la commune de Kinshasa sont liées, de
Dieudonné NGONDO WA NGONDO
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