Results 41 to 50 of about 2,082,669 (307)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Gouvernance des Petites et Moyennes Entreprises dans la commune de Kinshasa [PDF]

Mouvements et Enjeux Sociaux
Les résultats de cette étude attestent de l’existence d’une forte corrélation entre la gouvernance et les performances dans les petites et moyennes entreprises familiales. Les performances des dirigeants des PME dans la commune de Kinshasa sont liées, de
Dieudonné NGONDO WA NGONDO
doaj  

Statistical analysis of the relation between human age and gender on the risk of death from cancer in head and neck CT-Scan [PDF]

مجله علوم و فنون هسته‌ای
The purpose of this study was to investigate the effects of human age and gender on the estimation of the death risk due to cancer in head and neck CT scans.
R. Ahangari, M. Abdolalizadeh
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Financial Freedom, Social Capital, and the Development of Rural Women Entrepreneurship in India

Финансы: теория и практика
Human resource development can only be achieved by promoting female entrepreneurship. There is a very low level of female entrepreneurship in India, especially in rural areas, which has recently been a cause for concern.
M. Victor, N. Elangovan, D. Halaswamy, M. Sonia   +3 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Operational Efficiency and Leverage Effects in Driving Financial Performance: Firm Size Moderating in Indonesian Chemical Industry

Jurnal Cendekia Keuangan
Introduction/Main Objectives: Financial performance in Indonesia’s chemical subsector fluctuated during 2020–2024. Therefore, this study examines the effects of operational efficiency (BOPO) and leverage (DER) on financial performance (ROA), with firm ...
Ghaisani Lintang Rismayana, Erwin Budianto   +1 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

PENGARUH BUDAYA MASYARAKAT, PROSES PENGELOLAAN SAMPAH DAN RANTAI PASOK PENGELOLAAN SAMPAH DI KOTA SEMARANG

J@ti Undip: Jurnal Teknik Industri
Pengelolaan sampah di kawasan perkotaan seperti Kota Semarang menghadapi tantangan yang kompleks, terutama terkait peningkatan volume limbah dan efektivitas distribusi dari sumber ke tempat pemrosesan akhir.
Hanifah Septiani Wulandari, Ratih Setyaningrum   +1 more
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source