Results 61 to 70 of about 149,319 (312)

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source

Review of Douglas Thomas, “Hacker Culture” [PDF]

, 2005
This article reviews the book '“Hacker Culture” by Douglas ...
Legg, Catherine
core   +1 more source

Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits

Advanced Science, EarlyView.
A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao, Hanpeng Luo, Dailu Guan, Xuefeng Fu, Feng Wang, Guoming Zhang, Shanglai Li, Hua Yang, Yanli Zhang   +8 more
wiley   +1 more source

pySPT: a package dedicated to the source position transformation

, 2018
The modern time-delay cosmography aims to infer the cosmological parameters with a competitive precision from observing a multiply imaged quasar. The success of this technique relies upon a robust modeling of the lens mass distribution.
Orthen, Bastian, Wertz, Olivier
core   +1 more source

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

Engineered Strain in 2D Materials by Direct Growth on Deterministically Patterned Grayscale Topographies

Advanced Science, EarlyView.
ABSTRACT Strain is a proven technique for modifying the bandgap and enhancing carrier mobility in 2D materials. Most current strain engineering techniques rely on the post‐growth transfer of these atomically thin materials from growth substrates to target surfaces, limiting their integration into nanoelectronics.
Berke Erbas, Arindam Bala, Hernan Furci, Anushree Dutta, Naresh Kumar, Renato Zenobi, Giovanni Boero, Andras Kis, Juergen Brugger   +8 more
wiley   +1 more source

The spt-function of Andrews

, 2017
57 pages, 6 figures. An early version has been published in Surveys in Combinatorics 2017, A. Claesson, M. Dukes, S. Kitaev, D. Manlove and K. Meeks, Eds., Cambridge University Press, Cambridge, 2017, pp.
openaire   +5 more sources

Optical Spectroscopy and Velocity Dispersions of Galaxy Clusters from the SPT-SZ Survey

, 2014
We present optical spectroscopy of galaxies in clusters detected through the Sunyaev-Zel'dovich (SZ) effect with the South Pole Telescope (SPT). We report our own measurements of $61$ spectroscopic cluster redshifts, and $48$ velocity dispersions each ...
Aird, K. A., Armstrong, R., Ashby, M. L. N., Bautz, M., Bayliss, M., Bazin, G., Benson, B. A., Bleem, L. E., Bocquet, S., Brodwin, M., Carlstrom, J. E., Chang, C. L., Chapman, S. C., Cho, H. M., Clocchiatti, A., Crawford, T. M., Crites, A. T., de Haan, T., Desai, S., Dobbs, M. A., Dudley, J. P., Foley, R. J., Forman, W. R., George, E. M., Gladders, M. D., Gonzalez, A. H., Halverson, N. W., Harrington, N. L., High, F. W., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Jones, C., Joy, M., Keisler, R., Knox, L., Lee, A. T., Leitch, E. M., Liu, J., Lueker, M., Luong-Van, D., Mantz, A., Marrone, D. P., McDonald, M., McMahon, J. J., Mehl, J., Meyer, S. S., Mocanu, L., Mohr, J. J., Montroy, T. E., Murray, S. S., Natoli, T., Nurgaliev, D., Padin, S., Plagge, T., Pryke, C., Reichardt, C. L., Rest, A., Ruel, J., Ruhl, J. E., Saliwanchik, B. R., Saro, A., Sayre, J. T., Schaffer, K. K., Shaw, L., Shirokoff, E., Song, J., Spieler, H. G., Stalder, B., Stanford, S. A., Staniszewski, Z., Stark, A. A., Story, K., Stubbs, C. W., van Engelen, A., Vanderlinde, K., Vieira, J. D., Vikhlinin, A., Williamson, R., Zahn, O., Zenteno, A., Šuhada, R.   +81 more
core   +1 more source

Çukurca İlçesinin Yerleşime Uygunluk Açısından Değerlendirilmesi

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2015
Bu çalışmada, Çukurca ilçesinin yerleşimi için uygun, önlemli ve uygun olmayan alanların sınırlarının belirlenmesi amaç edinilmiştir. Bu amaca yönelik olarak, arazi çalışmaları kapsamında jeolojik birimlerin litolojik sınırları çizilmiş, tektonik hatlar ...
Adil Özdemir, Ali Ateş, Burak Yeşil
doaj