Results 41 to 50 of about 84,792 (273)

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

Advanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao, Ping Jiang, Xinli Zhou, Mengying Yin, Qiong Luo, Hui Wang   +5 more
wiley   +1 more source

Study on the Effect of Spur Dike Arrangement in Tidal Estuary on River Bed Scouring

Renmin Zhujiang, 2020
There are momentum and mass exchanges between rivers and its adjacent harbors, damfields and river channels. This paper analyzes the influence of different spur dike spacing onriver bed scouring by two-dimensional water-sediment model and theoretical ...
WANG Renchao, ZHANG Gongjin, HU Caixia, LIU Rui, WU Dongdong   +4 more
doaj  

Study on Spacing Threshold of Nonsubmerged Spur Dikes with Alternate Layout [PDF]

Journal of Applied Mathematics, 2013
This paper investigated the spacing threshold of nonsubmerged spur dikes with alternate layout to classify the impact scale of spur dikes. A mathematical model was built based on standardk-εmodel, finite volume method (FVM), and rigid lid assumption and was verified by experimental data.
Xiaomeng Cao, Zhenghua Gu, Hongwu Tang
openaire   +4 more sources

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Numerical Simulation of Turbulent Flow and Local Scouring Around of Spur Dike Straight and Angles by FLOW-3D [PDF]

علوم و مهندسی آبیاری, 2016
Examining the properties and behavior of the flow in the rivers and its associated structures is one of complex phenomena that make the use of software inevitable. First, the results of laboratory test carried out by Duan et al.
Mojtaba Asadi, Seyed Mohammad Ali Zomorodian   +1 more
doaj   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Dynamic-Geomorphic Coupling Mechanism Influencing Sediment Deposition Intensity in Tidal Estuarine Bar Fields:A Case Study of Spur Dike Fields in the North Passage of Yangtze River Estuary [PDF]

长江科学院院报
[Objective] This study centers on the dike fields of the spur dike group in the Yangtze River Estuary, a typical tidal estuary where complex water-sediment dynamics and diverse dike layouts jointly shape deposition processes.
ZHANG Gong-jin, QIAN Ming-xia, ZHU Xian-bo
doaj   +1 more source

Investigation of the Effects of Submerged Vanes and Spur Dikes on Sediment Control at Lateral Intakes by SSIIM2 Software [PDF]

علوم و مهندسی آبیاری, 2016
Sediment control at lateral intakes is known as a complicated issue for river engineers. In this study, numerical simulation of the impact of submerged vanes and spur dike on sediment control at lateral intake has been performed.
Edris Maroofi nia, Adel Asna Ashari, Yousef Hassan Zadeh, Saeid Khosh tinat, Babak Amin nejad   +4 more
doaj   +1 more source

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source