Results 31 to 40 of about 17,794 (305)

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

open access: yesAdvanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao   +12 more
wiley   +1 more source

Meshing Stiffness Calculation of Spur Bevel Gears Considering the Tooth Pair Coupling

open access: yesJixie chuandong, 2023
In order to solve the problem of calculation efficiency and accuracy of time-varying meshing stiffness of spur bevel gears, a slice calculation method of meshing stiffness of spur bevel gears considering the coupling effect of tooth pairs is proposed ...
Li Feifei, Dong Huimin, Zhang Chu
doaj  

Bidirectional torque filter eliminates backlash [PDF]

open access: yes, 1965
Two elastic springs connecting a hub and two spur gears absorb bidirectional step torque differentials and provide antibacklash characteristics between input and output shafts.
Baker, R., Veilette, L., Williams, S.
core   +1 more source

Characteristics, Management, and Utilization of Muscles in Musculoskeletal Humanoids: Empirical Study on Kengoro and Musashi

open access: yesAdvanced Intelligent Systems, EarlyView.
Musculoskeletal humanoids exhibit rich biomechanical properties that remain insufficiently unified in prior discussions. This article systematically categorizes muscle characteristics into five properties: redundancy, independency, anisotropy, variable moment arm, and nonlinear elasticity, and analyzes their combined effects on control.
Kento Kawaharazuka   +2 more
wiley   +1 more source

A One-Dimensional Convolutional Neural Network-Based Method for Diagnosis of Tooth Root Cracks in Asymmetric Spur Gear Pairs

open access: yesMachines, 2023
Gears are fundamental components used to transmit power and motion in modern industry. Their health condition monitoring is crucial to ensure reliable operations, prevent unscheduled shutdowns, and minimize human casualties.
Onur Can Kalay   +3 more
doaj   +1 more source

Bayesian Optimisation for the Experimental Sciences: A Practical Guide to Data‐Efficient Optimisation of Laboratory Workflows

open access: yesAdvanced Intelligent Systems, EarlyView.
This study provides an introduction to Bayesian optimisation targeted for experimentalists. It explains core concepts, surrogate modelling, and acquisition strategies, and addresses common real‐world challenges such as noise, constraints, mixed variables, scalability, and automation.
Chuan He   +2 more
wiley   +1 more source

Perfeccionamiento del diseño de transmisiones por engranajes cilíndricos de dientes rectos interiores

open access: yesRevista Científica, 2012
his paper presents research results of the article that bears his name. In this regard, the gears have cylindrical inner spur have their peculiarities with respect to the spur gear outer cylindrical in their geometry and cha- racteristics of the contact ...
Ana María Becerra Ferreiro   +3 more
doaj  

CFD Investigation on Oil Injection Lubrication of Meshing Spur Gears via Lattice Boltzmann Method

open access: yesLubricants, 2022
The meshless Lattice Boltzmann Method (LBM) is introduced and employed to solve the complex two-phase flow problem of jet lubrication of meshing spur gears. Computational fluid dynamics (CFD) simulations based on LBM are carried out using the model of an
Xiaozhou Hu   +3 more
doaj   +1 more source

The role of Research‐Practice Ambassadors in strengthening socially just and equitable partnership processes

open access: yesAmerican Journal of Community Psychology, EarlyView.
Abstract Research‐Practice Partnerships seek to close the research‐practice gap through developing collaborative, authentic partnerships between researchers and community members. Our team has leveraged Research‐Practice Ambassadors to support socially just and equitable partnership processes in schools.
Danielle R. Hatchimonji   +8 more
wiley   +1 more source

Влияние модификации в виде проточки вдоль вершины зуба на его изгибную жёсткость [PDF]

open access: yes, 2005
Розглядається один із шляхів підвищення працездатності прямозубих коліс. Виконується розрахунок об'ємного пружно-деформованого стану модифікованих прямозубих коліс методом скінчених елементів.
Бережной, Виталий Александрович   +1 more
core  

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