Results 81 to 90 of about 805,583 (361)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Sub-Sets of Cancer Stem Cells Differ Intrinsically in Their Patterns of Oxygen Metabolism [PDF]

, 2013
PMCID: PMC3640080This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Adrian Biddle, Anne C. Johannessen, DM Brizel, E Gemenetzidis, E Louie, E Sasabe, E Sasabe, G Dontu, GL Semenza, H Wang, H Zhang, H Zhong, Hannah K. Heywood, HK Heywood, I Papandreou, Ian C. Mackenzie, JP Thiery, JW Kim, LJ Harper, LJ Harper, Luke Gammon, M Al-Hajj, M Diehn, M Wartenberg, ME Prince, MF Clarke, MH Yang, MH Yang, MK Ayrapetov, O Warburg, O Warburg, P van Uden, PB Gupta, PD Sutphin, PJ Kallio, Q Li, R Sullivan, RD Lester, SA Mani, SM Wigfield, SS Prime, T Brabletz, T McFate, Yao Liang Tang   +43 more
core   +3 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Triage of women with equivocal or low-grade cervical cytology results: a meta-analysis of the HPV test positivity rate [PDF]

, 2009
Introduction Methods Results Discussion Conclusion Abstract Consistent evidence underlines the utility of human papillomavirus (HPV) DNA testing in the management of women with equivocal cervical cytological abnormalities, but not in case of low-grade ...
ALTS group, Anonymous, Andersson, Arbyn, Arbyn, Arbyn, Arbyn, Arbyn, Arbyn, Arbyn, Arias-Pulido, ASCUS-LSIL Triage Study Group, ASCUS-LSIL Triage Study Group, Bais, Bergeron, Bergeron, Berkhof, Bibbo, Boardman, Bradburn, Bruner, Carozzi, Castle, Clifford, Cochran, Coleman, Cuschieri, Cuzick, Dalla Palma, Depuydt, Dersimonian, Dudding, European Commission, Evans, Ferris, Franceschi, Giovannelli, Guido, Guyot, Harris, Higgins, Holowaty, Jordan, Kadish, Kelly, Kendall, Kiatpongsan, Ko, Ko, Kulasingam, Kurman, Kyrgiou, Lau, Lee, Legood, Light, Lin, Llewellyn, Lonky, Luff, Lytwyn, Manos, McNutt, Melnikow, Molden, Monsonego, Morin, Moss, Nieh, Pretorius, Rebello, Ronco, Rowe, Sasieni, Sawaya, Schiffman, Schiffman, Selvaggi, Sharp, Sharp, Sherman, Shlay, Solomon, Solomon, Solomon, Sutton, Thompson, Tsoumpou, von Knebel, Wensveen, Wentzensen, Wright, Wright, Wright, Wright, You, Zhang, Zielinski, zur Hausen   +97 more
core   +1 more source

Corrigendum: Contrast-Enhanced CT-Based Radiomics Analysis in Predicting Lymphovascular Invasion in Esophageal Squamous Cell Carcinoma [PDF]

, 2021
Li Yang, Meng Yu, Guangda Wang, Yang Li, Chongfei Ma, Ming‐Bo Wang, Meng Yue, Mengdi Cong, Jialiang Ren, Gaofeng Shi   +9 more
openalex   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Actinic keratoses show variable histological basal growth patterns - a proposed classification adjustment [PDF]

, 2017
Background: Common histological classification schemes of actinic keratoses (AK) do not evaluate growth patterns at basal epidermal aspects of AK. Until now, the importance of basal epidermal growth patterns of AK has not been studied. Objective: To
Dirschka, T., Gambichler, T., Gupta, G., Schmitz, L., Stockfleth, E., Stücker, M., Szeimies, R.M.   +6 more
core   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Human papillomavirus genotyping among the women with cervical abnormalities in Ulaanbaatar, Mongolia [PDF]

, 2019
学位記番号 ...
TSEDENBAL, BATCHIMEG, TSEDENBAL, BATCHIMEG, ツェデンバル, バトチメグ   +2 more
core