Results 171 to 180 of about 1,404,226 (404)
Advanced Science, EarlyView.Nrf2 isn't just a protector—it's a driver of cancer stemness. The study uncovers how arsenic‐activated Nrf2 directly upregulates KLF4, a key pluripotency factor, fueling oncogenic reprogramming. Through enhancer activation and self‐reinforcing loop, Nrf2 and KLF4 co‐opt gene networks linked to epithelial‐to‐mesenchymal transition and tumor growth ...
Ziwei Wang +9 more
wiley +1 more source
Treatment Outcome of Cervical Cancer Patients at Ocean Road Cancer Institute, Dar es salaam [PDF]
, 2011 Cervical cancer is the second commonest malignancy in females globally. Cancer of the cervix has a devastating impact on women’s health in developing countries especially Africa since more than 75% of the worldwide burden of the disease occurs in these ...
Majinge, Peter MC
core
The GGH/HuR Complex Binds and Stabilizes mRNAs to Maintain Tumor Cell Cycle and DNA Replication
Advanced Science, EarlyView.Despite its canonical role in inhibiting DNA synthesis, GGH promotes tumor growth as a novel RNA‐binding protein. GGH binds GC‐rich 5′UTRs (e.g., CDC6/CCND1), recruits HuR to form a ternary complex that stabilizes mRNA via circular conformation, fueling DNA replication and the cell cycle. Targeting this axis suppresses NSCLC progression.
Yu Li +9 more
wiley +1 more source
The Surgical Treatment of a Case of Radiated Postcricoid Squamous Cell Carcinoma in Spite of Lung-shadow [PDF]
, 1959 J. Springorum
openalex +1 more source
Advanced Science, EarlyView.The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang +15 more
wiley +1 more source
Multiple Heterotopic Squamous-cell Carcinomas [PDF]
, 1958 JEFF EVANS, Ariela Pomerance
openalex +1 more source
STK25 Loss Augments Anti‐PD‐1 Therapy Efficacy by Regulating PD‐L1 Stability in Colorectal Cancer
Advanced Science, EarlyView.This study demonstrates that STK25 depletion facilitates CRC immune escape through the inhibition of PD‐L1 Ser283 phosphorylation‐mediated ubiquitination, and promotes tumor growth. Furthermore, these findings identify STK25 as a potential therapeutic target to trigger antitumor immunity and promote immunotherapy efficacy. Abstract Tumor immune evasion
Xiaowen Qiao +20 more
wiley +1 more source
Squamous cell carcinoma associated with tall cell variant of papillary carcinoma of the thyroid
Indian Journal of Pathology and Microbiology, 2010 We report the simultaneous occurrence of the tall cell variant of papillary carcinoma and squamous cell carcinoma in the thyroid gland. Histology and immunohistochemical findings are discussed and it seems that the malignant squamous component was ...
Ashraf M +3 more
doaj
Squamous Cell Carcinoma Occurring in Asbestosis of the Lung
, 1948 R. J. R. Cureton
openalex +1 more source
The Mutational Landscape of Head and Neck Squamous Cell Carcinoma
Science, 2011 Nicolas Stransky +38 more
semanticscholar +1 more source