Results 191 to 200 of about 1,404,226 (404)

From Bench to Bedside: Emerging Paradigms in CAR‐T Cell Therapy for Solid Malignancies

Advanced Science, EarlyView.
This review discusses emerging paradigms in CAR‐T cell therapy for solid tumors, emphasizing strategies to overcome therapeutic barriers through synthetic biology, immune engineering, and combinatorial approaches. It highlights advancements in logic gating, modulation of the immune microenvironment, and innovative cell designs, providing valuable ...
Yang Chen, Ran Ren, Lirong Yan, Yu Zhou, Ruokai Sun, Huicong Song, Hongfei Yan, Yongsheng Li   +7 more
wiley   +1 more source

Single-cell sequencing reveals PHLDA1-positive smooth muscle cells promote local invasion in head and neck squamous cell carcinoma

Translational Oncology
Background: Smooth muscle cells within the tumor microenvironment play a crucial role in cancer progression. However, their involvement in the local invasion of head and neck squamous cell carcinoma remains poorly understood.
Bing Guo, Xutao Wen, Shun Yu, Jun Yang
doaj   +1 more source

Differentiating between Squamous Cell Carcinoma and Pigmented Squamous Cell Carcinoma [PDF]

Ear, Nose & Throat Journal, 2005
William E. Chapman, Christopher Y. Chang, Julia A. Furdyna   +2 more
openaire   +2 more sources

Serine/Threonine Kinase 33 as a Novel Target of Bufalin in Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study identified that STK33 may serve as a target of Bufalin, which induces the degradation of STK33 and inhibits the growth of TNBC. Furthermore, STK33 is highly expressed in TNBC and enhances TNBC cell proliferation by phosphorylating and stabilizing CCAR1.
Shilong Jiang, Junyan Liu, Hui Li, Chan Zou, Xiaoya Wan, Rong Gong, Ting Jiang, Changxin Zhong, Zonglin Chen, Zewu Zhu, Dongsheng Cao, Yan Cheng   +11 more
wiley   +1 more source

Porphyrin Fluorescence of Experimentally produced Squamous Cell Carcinoma [PDF]

, 1960
F. N. Ghadially, W. J. P. Neish
openalex   +1 more source

Spatial Transcriptomics Reveals Transcriptomic and Immune Microenvironment Reprogramming during Thyroid Carcinoma Dedifferentiation

Advanced Science, EarlyView.
Spatial transcriptomic analysis of Anaplastic thyroid carcinoma (ATC)‐differentiated thyroid carcinoma (DTC) coexisting tumors reveals that coexisting DTC regions with ATC‐like genomic alterations undergo sequential transcriptomic reprogramming and immune microenvironment remodeling, ultimately evolving into a full ATC pathological phenotype.
Kang Ning, Bu Zou, Yongchao Yu, Taonong Cai, Zhenyu Luo, Yu Guo, Yi Wu, Xiujiao Shen, Hao Li, Mengyuan Fang, Jian Bu, Han Hong, Zan Jiao, Tong Wu, Yulong Wang, Tianrun Liu, Weichao Chen, Wanming Hu, Mingjie Jiang, Ankui Yang   +19 more
wiley   +1 more source

Bronchogenic squamous cell carcinoma metastasizing to Bowman's capsule [PDF]

, 1966
L. Ross
openalex   +1 more source

Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism‐Dependent and ‐Independent Mechanisms

Advanced Science, EarlyView.
In KRAS‐mutant tumors, KRAS transcriptionally upregulates COA4 via the PI3K/AKT/E2F1 axis, promoting metastasis. Mechanistically, COA4 enhances tumor cell migration through dual pathways: within mitochondria, it boosts oxidative phosphorylation; in the cytoplasm, it binds and activates CDC42 to stimulate pseudopodia formation.
Xingzhao Ji, Weiying Zhang, Fuyuan Xue, Jiazhen Zeng, Qinghua Zhao, Xiaoming Sun, Jian Sun, Heng Zhou, Quanlin Xu, Guoyuan Ma, Shengnan Sun, Ying Wang, Qian Mu, Yi Liu, Qiang Wan   +14 more
wiley   +1 more source

Relationship between TLR4 and NF-κB p65 protein expressions and clinical radiosensitivity of patients with esophageal squamous cell carcinoma [PDF]

, 1969
Hua Tang, Feng Wang, Xifa Zhou, Jian Zhou, Ling Chen, Judong Luo, Enci Xu   +6 more
openalex   +1 more source

Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck.

New England Journal of Medicine, 2004
J. Cooper, T. Pajak, A. Forastiere, J. Jacobs, B. Campbell, S. Saxman, J. Kish, Harold Kim, A. Cmelak, M. Rotman, M. Machtay, J. Ensley, K. Chao, C. Schultz, N. Lee, K. Fu   +15 more
semanticscholar   +1 more source