Results 241 to 250 of about 1,427,322 (409)

GSH as an A‐A Type Allosteric Activator of PKM2: Modulating Cancer Cell Homeostasis and Ferroptosis Susceptibility

open access: yesAdvanced Science, EarlyView.
Glutathione (GSH) defines oxidative balance, but can it directly tune central metabolism? The research reveals that GSH binds and potently activates pyruvate kniase M2 (PKM2), rewiring glycolysis and dictating ferroptosis sensitivity. Combining GSH depletion with PKM2 activation triggers mitochondrial damage and lipid peroxidation, profoundly ...
Tsan‐Jan Chen   +17 more
wiley   +1 more source

Location characteristics of superficial esophageal squamous cell carcinoma. [PDF]

open access: yesSci Rep
Ryu DG   +7 more
europepmc   +1 more source

Significance of Serum Tumor Markers in Esophageal and Gastric Cancers: A Systematic Literature Review

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim Serum tumor markers are helpful for diagnosis, monitoring treatment outcomes, and prognosis. However, their clinical utility for esophageal squamous cell carcinoma (ESCC) and gastric cancer (GC) remains unclear. This study aimed to comprehensively evaluate recent studies on serum tumor markers in ESCC and GC.
Yasunori Matsumoto   +2 more
wiley   +1 more source

Inhibition of autophagy augments apoptosis in human oral squamous cell carcinoma under nutrient depletion [PDF]

open access: bronze, 2014
Li‐Cheng Jiang   +10 more
openalex   +1 more source

Dis Esophagus [PDF]

open access: yes
The incidence of esophageal adenocarcinoma in the United States has risen rapidly over the last 30 years, whereas the incidence of esophageal squamous cell carcinoma has fallen dramatically.

core  

Conversion Therapy for cT4b and M1 Esophageal Squamous Cell Carcinoma: A Comprehensive Systematic Review

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
We systematically reviewed conversion therapy for esophageal squamous cell carcinoma and propose a response‐based treatment strategy for cT4b and M1 disease. For cT4b, we emphasize definitive chemoradiotherapy with timed re‐evaluation and selective salvage or chemoselection to surgery; for M1, conversion is reserved for limited‐burden responders with ...
Eisuke Booka, Hiroya Takeuchi
wiley   +1 more source

Impact of Circular Stapler Size on Short‐Term Outcomes and Long‐Term Quality of Life After McKeown Esophagectomy

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
In this study, we investigated the impact of circular stapler size on both short‐term outcomes and long‐term QOL after McKeown esophagectomy. We revealed that short‐term outcomes, including anastomotic leakage and stenosis, did not differ between patients who underwent anastomosis with a 21 mm stapler and those with a 23 mm stapler.
Suguru Maruyama   +9 more
wiley   +1 more source

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