Results 1 to 10 of about 12,534 (200)

Utility of SOX2 in the diagnosis of squamous intraepithelial lesions and squamous cell carcinoma of cervix uteri [PDF]

BMC Women's Health
Background The objective of this study was to examine the association between SOX2 expression and diagnostic and prognostic data in precancerous and cancerous lesions of the cervix uteri. It was postulated that SOX2 immunohistochemistry has the potential
Merve Bozkurt Kaya, Evren Uzun
doaj   +4 more sources

Topical Imiquimod for the Treatment of High-Grade Squamous Intraepithelial Lesions of the Cervix: A Randomized Controlled Trial. [PDF]

Obstet Gynecol, 2021
OBJECTIVE: To evaluate the histologic response rate of high-grade squamous intraepithelial lesions (HSIL) of the cervix after topical application of 5% imiquimod cream. METHODS: In this phase II trial, women with cervical HSIL (cervical intraepithelial neoplasia [CIN] 2–3) were ...
Fonseca BO, Possati-Resende JC, Salcedo MP, Schmeler KM, Accorsi GS, Fregnani JHTG, Antoniazzi M, Pantano NP, Santana IVV, Matsushita GM, Dos Reis R.   +10 more
europepmc   +4 more sources

Synchronous Cervical and Vulvar High-Grade Squamous Intraepithelial Lesions with Unusual p16/p53 Immunophenotype: A Case Report [PDF]

Reports
Background and Objectives: Synchronous cervical and vulvar squamous intraepithelial lesions are rarely reported. In most cases, these lesions are associated with high-risk human papillomavirus (HPV) infection and follow the conventional HPV-related ...
Catalin-Bogdan Satala, Alina-Mihaela Gurau, Andrei-Ionut Patrichi, Andreea Onofrei (Popa), Daniela Mihalache   +4 more
doaj   +2 more sources

Ki-67 expression in squamous intraepithelial lesions of the uterine cervix [PDF]

Archive of Oncology, 2006
BACKGROUND: Uncontrolled cell proliferation and malignant transformation are the basic elements in the development of malignant disease including cervical cancer and its precursors.
Panjković Milana, Ivković-Kapicl Tatjana   +1 more
doaj   +3 more sources

Risk stratification and anal cancer screening in immunocompetent women with genital HPV: Value of multicentric HSIL and performance of HPV-based screening. [PDF]

Int J Cancer
What's new? Anal squamous cell carcinoma (ASCC) incidence is increasing, with most cases occurring in immunocompetent women. ASCC risk is linked in particular to genital human papillomavirus (HPV) infection and HPV‐associated high‐grade squamous intraepithelial lesions (HSILs).
Matas I, Torné A, Saco A, Martí C, Cardiel A, Rakislova N, Marimon L, Glickman A, Victoria I, Alós S, Lopez-Diaz J, Fusté P, Ordi J, Del Pino M.   +13 more
europepmc   +2 more sources

Pregnancy outcomes among women with and without HIV infections who underwent excisional treatment for high-grade cervical intraepithelial neoplasia: a retrospective cohort study in low-resource settings [PDF]

BMJ Open
Objective The standard treatment for high-grade squamous intraepithelial lesions is excisional involving the uterine cervix, while surveillance is an acceptable approach for low-grade squamous intraepithelial lesions.
Susan Cu-Uvin, Peter Itsura, Benjamin Elly Odongo, Poli Philippe Amubuomombe, Philiph K Tonui, Elkanah Omenge Orang’o, Patrick Joseph Loehrer   +6 more
doaj   +2 more sources

Switches of SOX17 and SOX2 expression in the development of squamous metaplasia and squamous intraepithelial lesions of the uterine cervix [PDF]

Cancer Medicine, 2020
Aims The dynamics and topographical distribution of SOX17 and SOX2 expression was studied in the transformation zone (TZ) of the uterine cervix. This TZ is a dynamic area where switches from glandular into squamous epithelium can be recognized, new ...
Jobran M. Moshi, Klaas J. Hoogduin, Monique Ummelen, Mieke E. R. Henfling, Manon vanEngeland, Kim A. D. Wouters, Hans Stoop, Imke Demers, Leendert H. J. Looijenga, Frans C. S. Ramaekers, Anton N. H. Hopman   +10 more
doaj   +4 more sources

The value of Ki67 for the diagnosis of LSIL and the problems of p16 in the diagnosis of HSIL

Scientific Reports, 2022
p16 and Ki67 are immunohistochemical markers related to cervical squamous intraepithelial lesions. p16 has been widely used to assist in the diagnosis of high-grade squamous intraepithelial lesions.
Jixuan Liu, Sanmei Su, Yafang Liu
doaj   +1 more source

Our approach to squamous intraepithelial lesions of the uterine cervix [PDF]

Journal of Clinical Pathology, 2006
Morphological analysis remains the “gold standard” in the diagnosis and grading of CIN Cervical carcinoma is a significant contributor to cancer-related morbidity and mortality worldwide and the role of human papillomavirus (HPV) in the development of preinvasive and invasive cervical lesions is well established.1,2 Although significant advances have ...
Alexandra N, Kalof, Kumarasen, Cooper
openaire   +2 more sources

Extensively Keratinized Squamous Intraepithelial Lesions of the Cervix Are Difficult to Grade [PDF]

American Journal of Clinical Pathology, 2001
We tested the hypothesis that extensively keratinized squamous intraepithelial lesions (SILs) are difficult to grade precisely by identifying 100 Papanicolaou smears with a keratinizing SIL that had been originally judged difficult to grade. Of these, 65 were confirmed as low-grade SIL (LSIL) or high-grade SIL (HSIL) on subsequent biopsy. The 65 smears
W C, Faquin, F M, Brown, J F, Krane, A A, Renshaw, E S, Cibas   +4 more
openaire   +2 more sources