Results 181 to 190 of about 2,499,965 (359)

Modeling General Asymptotic Calabi–Yau Periods

Fortschritte der Physik, EarlyView.
Abstract In the quest to uncovering the fundamental structures that underlie some of the asymptotic Swampland conjectures the authors initiate the general study of asymptotic period vectors of Calabi–Yau manifolds. The strategy is to exploit the constraints imposed by completeness, symmetry, and positivity, which are formalized in asymptotic Hodge ...
Brice Bastian, Thomas W. Grimm, Damian van de Heisteeg   +2 more
wiley   +1 more source

Target‐Mediated Drug Disposition (TMDD) Revisited: High Versus Low‐Affinity Approximations of the TMDD Model

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Target‐mediated drug disposition (TMDD) is often associated with high‐affinity binding to a target resulting in nonlinear pharmacokinetics. For large molecules, such as monoclonal antibodies, this can lead to increased clearance at sub‐saturating concentrations.
Ronny Straube
wiley   +1 more source

Geometry of Hermitian Algebraic Functions. Quotients of Squared Norms [PDF]

, 2008
Dror Varolin
openalex   +1 more source

A Pharmacometric Workflow for Resolving Model Instability in Model Use‐Reuse Settings

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT The development of fit‐for‐purpose pharmacokinetic‐pharmacodynamic (PKPD) models based on clinical and pre‐clinical data is a critically important process in model informed drug development. This process is often hampered by modeling stability issues that are often multifactorial in nature and difficult to overcome, leading to protracted model
Stephen B. Duffull, Daniel F. B. Wright, Xiao Zhu, Xin Liu, Ahmed Abulfathi, Hailemichael Hishe   +5 more
wiley   +1 more source

Unbiased calculation, evaluation, and calibration of ensemble forecast anomalies

Quarterly Journal of the Royal Meteorological Society, EarlyView.
Standard methods for calculating ensemble forecast anomalies result in statistical inconsistencies between forecast and verification anomalies, even if the underlying forecasts are perfectly reliable. An unbiased evaluation of anomaly‐based ensemble forecasts must account for differences in climatological sampling uncertainty between forecasts and ...
Christopher D. Roberts, Martin Leutbecher   +1 more
wiley   +1 more source

Relative Errors Versus Residuals of Approximate Solutions to Linear Algebraic Equations and Least Squares Problems

, 2001
Jiu Ding
openalex   +1 more source

Hyperspheres and hyperplanes fitted seamlessly by algebraic constrained total least-squares

, 2001
Yves Nievergelt
openalex   +1 more source

Blowup Algebras of Square-Free Monomial Ideals and Some Links to Combinatorial Optimization Problems [PDF]

, 2009
Isidoro Gitler, Enrique Reyes, Rafael H. Villarreal   +2 more
openalex   +1 more source

Quantum gravity: are we there yet? [PDF]

Philos Trans A Math Phys Eng Sci
Majid S.
europepmc   +1 more source

Toward Useful Quantum Kernels

Advanced Quantum Technologies, EarlyView.
The hybrid approach to Quantum Supervised Machine Learning is compatible with Noisy Intermediate Scale Quantum (NISQ) devices but hardly useful. Pure quantum kernels requiring fault‐tolerant quantum computers are more promising. Examples are kernels computed by means of the Quantum Fourier Transform (QFT) and kernels defined via the calculation of ...
Massimiliano Incudini, Francesco Martini, Alessandra Di Pierro   +2 more
wiley   +1 more source