Results 111 to 120 of about 4,479,797 (370)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Distributed hybrid consensus–based square-root cubature quadrature information filter and its application to maneuvering target tracking

open access: yesInternational Journal of Distributed Sensor Networks, 2019
To handle nonlinear filtering problems with networked sensors in a distributed manner, a novel distributed hybrid consensus–based square-root cubature quadrature information filter is proposed.
Jun Liu   +5 more
doaj   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

open access: yesFEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah   +8 more
wiley   +1 more source

Asymptotic Ray Method for the Double Square Root Equation

open access: yesJournal of Marine Science and Engineering
The parabolic wave equation describes wave propagation in a preferable direction, which is usually horizontal in underwater acoustics and vertical in seismic applications.
Nikolay N. Shilov, Anton A. Duchkov
doaj   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

open access: yesFEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Critical point approaches to nonlinear square root Laplacian equations

open access: yesMiskolc Mathematical Notes
This work is devoted to the study of multiplicity results of solutions for a class of nonlinear equations involving the square root of the Laplacian. Indeed, we will use variational methods for smooth functionals, defined on reflexive Banach spaces, in ...
Martin Bohner   +3 more
doaj   +1 more source

On the Uniform Convergence of Sine Series with Square Root

open access: yesJournal of Function Spaces, 2019
Chaundy and Jolliffe proved that if {ck}k=1∞ is a nonincreasing real sequence with limk→∞ck=0, then the series ∑k=1∞‍cksin⁡kx converges uniformly if and only if kck→0.
Sergiusz Kęska
doaj   +1 more source

A Note on a "Square-Root Rule" for Reinsurance [PDF]

open access: yes
In previous work, the current authors derived a mathematical expression for the optimal (or "saturation") number of reinsurers for a given number of primary insurers (see Powers and Shubik, 2001).
Martin Shubik, Michael R. Powers
core  

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