Results 321 to 330 of about 886,309 (341)

SR-BI and cholesterol uptake into steroidogenic cells

Trends in Endocrinology & Metabolism, 2003
Scavenger receptor class B, type I (SR-BI) is a receptor for high-density lipoprotein (HDL) that mediates cellular uptake of HDL cholesteryl ester (HDL CE) and is the major route for cholesterol delivery to the steroidogenic pathway. SR-BI is localized in specialized microvillar channels in the plasma membrane that retain HDL and are sites of selective
Margery A. Connelly, David L. Williams
openaire   +3 more sources

SR‐BI and HDL Cholesteryl Ester Metabolism

Endocrine Research, 2004
Scavenger receptor class B, type I (SR-BI) is the receptor for high density lipoprotein (HDL) that mediates cellular uptake of HDL cholesteryl ester (CE) and is a major route for cholesterol delivery to steroidogenic pathways. SR-BI is localized in specialized microvillar channel plasma membrane compartments that retain HDL and are sites for HDL CE ...
Margery A. Connelly, David L. Williams
openaire   +3 more sources

The HDL Receptor SR-BI

2010
Scavenger receptor class B type I (SR-BI) was the first molecularly well-defined and functionally active cell surface HDL receptor to be described. SR-BI mediates the transfer of cholesterol from HDL to cells via a mechanism called selective lipid uptake. In vitro and in vivo studies have established that SR-BI is a physiologically relevant lipoprotein
Monty Krieger, Attilio Rigotti
openaire   +2 more sources

Insulin increases cholesterol uptake, lipid droplet content, and apolipoprotein B secretion in CaCo‐2 cells by upregulating SR‐BI via a PI3K, AKT, and mTOR‐dependent pathway

Journal of Cellular Biochemistry, 2018
The actions of insulin on intestinal cholesterol absorption and lipoprotein secretion are not well understood. Herein, we determined the effects of insulin on the levels of cholesterol transporter scavenger receptor, class B, type I (SR‐BI), cellular ...
M. Fuentes, Nicolás Santander, V. Cortés   +2 more
semanticscholar   +1 more source

SR-BI et métabolisme du cholestérol.

médecine/sciences, 1999
Dans la classe des recepteurs « eboueurs » (scavenger), le SR-BI (scavenger receptor class B type 1) murin, dont l'homologue humain est CLA1 (CD36 and LIMPII analogous-1), possede la fonction inattendue de lier les HDL, facilitant l'entree selective du cholesterol esterifie des HDL dans la cellule.
J. Ferezou, M. Combettes-Souverain, Claude Lutton, Fabien Milliat, C. Serougne   +4 more
openaire   +2 more sources

Resistivity of liquid SrBi and SrSb alloys

Journal of Non-Crystalline Solids, 1993
Abstract Recently, measurements of the electrical resistivity, ϱ, of the liquid SrBi and SrSb systems have been performed as a function of temperature for the entire concentration range. A very high and sharp resistivity maximum occurs at 60 at.% Sr for both systems, indicating that the mixture is semiconducting at this composition. Comparison with
W. van der Lugt, R. Xu
openaire   +2 more sources

SR-BI Mediates Cholesterol Efflux via Its Interactions with Lipid-Bound ApoE. Structural Mutations in SR-BI Diminish Cholesterol Efflux

Biochemistry, 2005
Apolipoprotein E (apoE) and the lipoprotein receptor SR-BI play critical roles in lipid and lipoprotein metabolism. We have examined the cholesterol efflux from wild-type (WT) and mutant forms of SR-BI expressed in ldlA-7 cells using reconstituted discoidal particles consisting of apoE, 1-palmitoyl-2-oleoyl-l-phospatidylcholine (POPC), and cholesterol (
Thomas J.F. Nieland, Kyriakos E. Kypreos, Vassilis I. Zannis, Angeliki Chroni, Monty Krieger   +4 more
openaire   +3 more sources

Role of SR-BI in regulating lipoprotein structure and metabolism

Drug News & Perspectives, 2001
The scavenger receptor class B type I (SR-BI) is a cell surface lipoprotein receptor that mediates physiologically relevant selective cholesteryl ester uptake from high-density lipoprotein (HDL). SR-BI appears to be required for the maintenance of reverse cholesterol transport, normal HDL levels and HDL structure by means of hepatic-selective HDL ...
openaire   +3 more sources

Developmental abnormalities in mouse embryos lacking the HDL receptor SR-BI.

Human Molecular Genetics, 2013
The srbi gene encodes a lipoprotein receptor with high affinity for high density lipoprotein that is mainly expressed in the liver and in steroidogenic tissues.
Nicolás Santander, S. Contreras-Duarte, Marian Awad, C. Lizama, I. Passalacqua, A. Rigotti, D. Busso   +6 more
semanticscholar   +1 more source

Overexpression of SR-BI in hamsters treated with a novel ACAT inhibitor (F12511)

Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie, 2001
The effect of a novel acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor on cholesterol metabolism was studied in hamsters. Oral administration of F12511 (10 mg/kg/d) for 4 weeks produced a decrease in dietary cholesterol absorption (-18%) and in the liver concentration of esterified cholesterol (-75%), as compared with control values in ...
Claude Lutton, Fabien Milliat, Jacqueline Férézou, André Delhon   +3 more
openaire   +3 more sources