Results 41 to 50 of about 180 (126)

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Efficacy of novel SARS-CoV2 vaccines in preventing SARS- CoV- 2 infection: a systematic review and meta-analysis

BMC Infectious Diseases
Background Efficacious SARS-CoV-2 vaccines are urgently required to prevent the spread of the emerging and re-emerging SARS-CoV-2. Objective Aim to assess the efficacy of novel SRAS-CoV-2 vaccines in preventing SARS-CoV-2 infection.
Zigale Hibstu Teffera, Wubetu Yihunie Belay, Bantayehu Addis Tegegne, Habtamu Belew, Adane Adugna, Yasabe Laykun, Samrawit Tefera, Yalew Muche, Abateneh Melkamu, Gashaw Azanaw Amare, Desalegn Abebaw, Yibeltal Akelew, Mohammed Jemal, Mamaru Getinet, Enyew Fenta Mengist, Temesgen Baylie, Aysheshim Belaineh Haimanot, Tiruzer Hibistu, Kassaye Enchalew   +18 more
doaj   +1 more source

L’impact du statut vaccinal sur l’importation de la COVID-19 chez les voyageurs internationaux

Canada Communicable Disease Report, 2021
Les gouvernements du monde entier cherchent des moyens de permettre les voyages internationaux en toute sécurité tout en atténuant la propagation du coronavirus du syndrome respiratoire aigu sévère 2 (SRAS-CoV-2) et de la maladie à coronavirus 2019 ...
Paul Ronksley, Tayler Scory, Robert Weaver, Meaghan Lunney, Rachel Rodin, Marcello Tonelli   +5 more
doaj  

Characterization of the SARS-CoV-2 genomes in Egypt in first and second waves of infection

Scientific Reports, 2021
At Wuhan, in December 2019, the SRAS-CoV-2 outbreak was detected and it has been the pandemic worldwide. This study aims to investigate the mutations in sequence of the SARS-CoV-2 genome and characterize the mutation patterns in Egyptian COVID-19 ...
Abdel-Rahman N. Zekri, Abeer A. Bahnasy, Mohamed M. Hafez, Zeinab K. Hassan, Ola S. Ahmed, Hany K. Soliman, Enas R. El-Sisi, Mona H. Salah El Dine, May S. Solimane, Lamyaa S. Abdel Latife, Mohamed G. Seadawy, Ahmed S. Elsafty, Mohamed Abouelhoda   +12 more
doaj   +1 more source

Pangenomic framework for globe artichoke supports SNP‐based varietal fingerprinting

The Plant Genome, Volume 19, Issue 4, December 2026.
Abstract Globe artichoke (Cynara cardunculus var. scolymus L.) comprises a broad range of local ecotypes and varietal groups whose genetic diversity has been investigated through different molecular markers. However, recent advances in next‐generation sequencing and pangenomic approaches provide new opportunities to capture genome‐wide variation at ...
Ezio Portis, Edoardo Vergnano, Luciana Gaccione, Alberto Acquadro, Cinzia Comino, Cristiano Carli, Lorenzo Barchi, Matteo Martina   +7 more
wiley   +1 more source

Neurosurgery Practice During the COVID-19 Pandemic

Iranian Journal of Neurosurgery, 2022
Background and Aim: The viral agent in severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) is the cause of the novel coronavirus disease 2019 (COVID-19).
Guive Sharifi, Navid Kalani, Akbar Kazemi, Ali Kazeminezhad   +3 more
doaj  

Coronavirus et la pratique ophtalmologique

Journal de la Société Marocaine d’Ophtalmologie, 2020
Le nouveau coronavirus a été initialement nommé 2019-nCoV et officiellement appelé coronavirus 2 du syndrome respiratoire aigu sévère (SRAS-CoV-2).
Hassan Moutei, ahmed Bennis, Fouad Chraibi, Meriem Abdellaoui, Idriss Andaloussi Benatiya   +4 more
doaj   +1 more source

Advances in Cytosolic dsRNA Sensing of Viral Infections

Immunology &Cell Biology, Volume 104, Issue 10, Page 975-986, November‐December 2026.
Activation of cytosolic dsRNA sensors by viral infection generates multiple outcomes. dsRNA generated during viral infection, either of viral origin or from endogenous sources, can activate multiple cytosolic dsRNA sensors. Activation of PKR critically induces protein translation shutdown via phosphorylation of eukaryotic translation initiation factor ...
Sofia Maceratessi, Natalia G. Sampaio
wiley   +1 more source

Medidas de prevención al odontólogo ante la epidemia causada por el coronavirus COVID-19

Revista Científica Especialidades Odontológicas UG, 2021
La microbiota de la cavidad bucal está compuesta por miles de microorganismos, incluidas bacterias, hongos y virus, que encuentran su nicho ideal en ella.
Thainah Bruna Santos Zambrano, Nataly Barreiro Mendoza   +1 more
doaj   +1 more source

Éthique et santé publique au temps du SRAS-CoV-2 : le fardeau des décideurs publics

Éthique publique, 2022
En 2020, le SRAS-CoV-2 a plongé le monde entier dans une crise sans précédent. Les structures sanitaires ont été mises à mal et le réseau de la santé a dû se réorganiser afin d’y faire face. Disposant de ressources limitées, les structures de santé publique et de soins de santé primaires se sont trouvées dans l’obligation d’effectuer rapidement des ...
Mathieu, Maryse, Girard, Jacques E., Talbot, David   +2 more
openaire   +2 more sources